Linked Life Data

19891487

Source:http://linkedlifedata.com/resource/pubmed/id/19891487

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
47
pubmed:dateCreated
2009-11-25
pubmed:abstractText
The concept of "hybrid helices" as a new motif for foldamers is presented. Hybrid helices can be realized by a combination of two or more different types of homologous and hybrid peptides, for example, beta-peptides and alpha/beta- and alpha/gamma-hybrid peptides, within the same oligomer. The different helix types of the various peptide foldamer classes are maintained and form a regular helix along the sequence of the oligomer. The transition from one helix type to another was found to be rather smooth with high compatibility of the different helix types. Such hybrid helices represent novel motifs of secondary structure scaffolds. They open up the possibility to change the direction of helix propagation in a subtle manner. Hybrid helices enrich the arsenal of defined foldamer structures for a structural and functional mimicry of native peptides and proteins.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1520-5126
pubmed:author
pubmed:issnType
Electronic
pubmed:day
2
pubmed:volume
131
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17335-44
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Hybrid helices: motifs for secondary structure scaffolds in foldamers.
pubmed:affiliation
Organic Chemistry Division III, Indian Institute of Chemical Technology (CSIR), Hyderabad 500 607, India. esmvee@iict.res.in
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't