| pubmed-article:19890787 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19890787 | lifeskim:mentions | umls-concept:C0013018 | lld:lifeskim |
| pubmed-article:19890787 | lifeskim:mentions | umls-concept:C0205653 | lld:lifeskim |
| pubmed-article:19890787 | lifeskim:mentions | umls-concept:C1883018 | lld:lifeskim |
| pubmed-article:19890787 | lifeskim:mentions | umls-concept:C0018129 | lld:lifeskim |
| pubmed-article:19890787 | lifeskim:mentions | umls-concept:C0445356 | lld:lifeskim |
| pubmed-article:19890787 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19890787 | pubmed:dateCreated | 2009-11-5 | lld:pubmed |
| pubmed-article:19890787 | pubmed:abstractText | Hematopoietic stem cell transplantation (HSCT) from a matched unrelated donor (MUD) has become the accepted salvage treatment for patients with severe aplastic anemia (SAA) lacking a matched sibling donor and failing immunosuppressive treatment. However, non-engraftment and early rejection remain main reasons for treatment related morbidity and mortality. We report on three adolescents who were grafted from MUD, rejected their graft and were re-grafted 47-51 days after first HSCT from the same donor. For conditioning, fludarabine, cyclophosphamide, ATG and/or OKT3 in combination with total lymphoid irradiation was used. Unmanipulated peripheral blood stem cells at a minimum dose of 8 x 10(6)/kg CD34+cells were infused. Acute toxicity was low. Two patients are alive and well for more than 3 years, one patient developed extended chronic graft-versus-host disease from which he died 34 months after second HSCT. Re-transplantation from MUD in the case of non-engraftment or rejection from the same donor is possible following immunoablation combined with intensive serotherapy in young patients with SAA. | lld:pubmed |
| pubmed-article:19890787 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19890787 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19890787 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19890787 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19890787 | pubmed:issn | 1439-3824 | lld:pubmed |
| pubmed-article:19890787 | pubmed:author | pubmed-author:KleinBB | lld:pubmed |
| pubmed-article:19890787 | pubmed:author | pubmed-author:ClaviezAA | lld:pubmed |
| pubmed-article:19890787 | pubmed:author | pubmed-author:HumpeAA | lld:pubmed |
| pubmed-article:19890787 | pubmed:author | pubmed-author:FührerMM | lld:pubmed |
| pubmed-article:19890787 | pubmed:author | pubmed-author:SchrauderAA | lld:pubmed |
| pubmed-article:19890787 | pubmed:copyrightInfo | Georg Thieme Verlag KG Stuttgart.New York. | lld:pubmed |
| pubmed-article:19890787 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19890787 | pubmed:volume | 221 | lld:pubmed |
| pubmed-article:19890787 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19890787 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19890787 | pubmed:pagination | 358-61 | lld:pubmed |
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| pubmed-article:19890787 | pubmed:articleTitle | Re-transplantation from the same unrelated donor in three adolescents with severe aplastic anemia after graft rejection. | lld:pubmed |
| pubmed-article:19890787 | pubmed:affiliation | Ludwig-Maximilian-University, Dr. von Haunersches Kinderspital, Department of Pediatric Oncology and Hematology, Munich, Germany. monika.fuehrer@med.uni-muenchen.de | lld:pubmed |
| pubmed-article:19890787 | pubmed:publicationType | Journal Article | lld:pubmed |
