Linked Life Data

19890787

Source:http://linkedlifedata.com/resource/pubmed/id/19890787

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-11-5
pubmed:abstractText
Hematopoietic stem cell transplantation (HSCT) from a matched unrelated donor (MUD) has become the accepted salvage treatment for patients with severe aplastic anemia (SAA) lacking a matched sibling donor and failing immunosuppressive treatment. However, non-engraftment and early rejection remain main reasons for treatment related morbidity and mortality. We report on three adolescents who were grafted from MUD, rejected their graft and were re-grafted 47-51 days after first HSCT from the same donor. For conditioning, fludarabine, cyclophosphamide, ATG and/or OKT3 in combination with total lymphoid irradiation was used. Unmanipulated peripheral blood stem cells at a minimum dose of 8 x 10(6)/kg CD34+cells were infused. Acute toxicity was low. Two patients are alive and well for more than 3 years, one patient developed extended chronic graft-versus-host disease from which he died 34 months after second HSCT. Re-transplantation from MUD in the case of non-engraftment or rejection from the same donor is possible following immunoablation combined with intensive serotherapy in young patients with SAA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1439-3824
pubmed:author
pubmed:copyrightInfo
Georg Thieme Verlag KG Stuttgart.New York.
pubmed:issnType
Electronic
pubmed:volume
221
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
358-61
pubmed:meshHeading
pubmed:articleTitle
Re-transplantation from the same unrelated donor in three adolescents with severe aplastic anemia after graft rejection.
pubmed:affiliation
Ludwig-Maximilian-University, Dr. von Haunersches Kinderspital, Department of Pediatric Oncology and Hematology, Munich, Germany. monika.fuehrer@med.uni-muenchen.de
pubmed:publicationType
Journal Article