| pubmed-article:19889630 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19889630 | lifeskim:mentions | umls-concept:C0042789 | lld:lifeskim |
| pubmed-article:19889630 | lifeskim:mentions | umls-concept:C0031760 | lld:lifeskim |
| pubmed-article:19889630 | lifeskim:mentions | umls-concept:C0035304 | lld:lifeskim |
| pubmed-article:19889630 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:19889630 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:19889630 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:19889630 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19889630 | pubmed:dateCreated | 2010-1-11 | lld:pubmed |
| pubmed-article:19889630 | pubmed:abstractText | In animals, visual pigments are essential for photoreceptor function and survival. These G-protein-coupled receptors consist of a protein moiety (opsin) and a covalently bound 11-cis-retinylidene chromophore. The chromophore is derived from dietary carotenoids by oxidative cleavage and trans-to-cis isomerization of double bonds. In vertebrates, the necessary chemical transformations are catalyzed by two distinct but structurally related enzymes, the carotenoid oxygenase beta-carotenoid-15,15'-monooxygenase and the retinoid isomerase RPE65 (retinal pigment epithelium protein of 65 kDa). Recently, we provided biochemical evidence that these reactions in insects are catalyzed by a single enzyme family member named NinaB. Here we show that in the fly pathway, carotenoids are mandatory precursors of the chromophore. After chromophore formation, the retinoid-binding protein Pinta acts downstream of NinaB and is required to supply photoreceptors with chromophore. Like ninaE encoding the opsin, ninaB expression is eye-dependent and is activated as a downstream target of the eyeless/pax6 and sine oculis master control genes for eye development. The requirement for coordinated synthesis of chromophore and opsin is evidenced by analysis of ninaE mutants. Retinal degeneration in opsin-deficient photoreceptors is caused by the chromophore and can be prevented by restricting its supply as seen in an opsin and chromophore-deficient double mutant. Thus, our study identifies NinaB as a key component for visual pigment production and provides evidence that chromophore in opsin-deficient photoreceptors can elicit retinal degeneration. | lld:pubmed |
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| pubmed-article:19889630 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19889630 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19889630 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19889630 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19889630 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19889630 | pubmed:issn | 1083-351X | lld:pubmed |
| pubmed-article:19889630 | pubmed:author | pubmed-author:HuberArminA | lld:pubmed |
| pubmed-article:19889630 | pubmed:author | pubmed-author:OberhauserVit... | lld:pubmed |
| pubmed-article:19889630 | pubmed:author | pubmed-author:MaguireMichae... | lld:pubmed |
| pubmed-article:19889630 | pubmed:author | pubmed-author:SumserEmerich... | lld:pubmed |
| pubmed-article:19889630 | pubmed:author | pubmed-author:von... | lld:pubmed |
| pubmed-article:19889630 | pubmed:author | pubmed-author:VoolstraOlafO | lld:pubmed |
| pubmed-article:19889630 | pubmed:author | pubmed-author:MeyerNina ENE | lld:pubmed |
| pubmed-article:19889630 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19889630 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19889630 | pubmed:volume | 285 | lld:pubmed |
| pubmed-article:19889630 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19889630 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19889630 | pubmed:pagination | 2130-9 | lld:pubmed |
| pubmed-article:19889630 | pubmed:dateRevised | 2011-7-20 | lld:pubmed |
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