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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-2-1
pubmed:abstractText
The prevalence of end-stage renal disease (ESRD) is uprising in the paralleled with the increase of chronic kidney disease (CKD) patients. Diabetic nephropathy (DN) is the most important underlying disease of CKD and a leading cause of ESRD in Japan. Intensified multifactorial intervention in patients with type 2 diabetes with microalbuminuria slows the progression to nephropathy, and progression of retinopathy and autonomic neuropathy. However, further studies are needed to establish the effect of intensified multifactorial treatment on DN with overt proteinuria. In this trial, doctors and co-medicals collaborate to treat the DN patients to prevent the deterioration of DN by multifactorial intensive therapy. Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT-Japan) is an open, randomized controlled trial to evaluate the efficacy of renal protection of multifactorial intensive therapy in type 2 diabetes patients with overt proteinuria (urinary albumin-to-creatinine ratio > or =300 mg/g creatinine). The study has a targeted enrollment of 600 Japanese patients, and divided into two protocols by renal insufficiency (protocol A: serum creatinine: <1.2mg/dl in male and <1.0mg/dl in female, and protocol B: serum creatinine: 1.2-2.5mg/dl in male and 1.0-2.5mg/dl in female). The patients were allocated standard treatment or intensive multifactorial treatment. Intensive treatment was a stepwise implementation of behavior modification, pharmacological therapy targeting hyperglycaemia, hypertension, dyslipidaemia, and proteinuria. The primary outcome is the proteinuria in protocol A and the composite endpoint of time to the first occurrence of doubling of serum creatinine, ESRD (the need for chronic dialysis, or renal transplantation) or death in protocol B. The follow-up period is 5 years and the study ends in 2014.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1872-8227
pubmed:author
pubmed:copyrightInfo
2009 Elsevier Ireland Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
228-32
pubmed:dateRevised
2010-6-7
pubmed:meshHeading
pubmed-meshheading:19889469-Adult, pubmed-meshheading:19889469-Aged, pubmed-meshheading:19889469-Albuminuria, pubmed-meshheading:19889469-Blood Glucose, pubmed-meshheading:19889469-Blood Pressure, pubmed-meshheading:19889469-Creatinine, pubmed-meshheading:19889469-Diabetes Mellitus, Type 2, pubmed-meshheading:19889469-Diabetic Diet, pubmed-meshheading:19889469-Diabetic Nephropathies, pubmed-meshheading:19889469-Disease Progression, pubmed-meshheading:19889469-Female, pubmed-meshheading:19889469-Humans, pubmed-meshheading:19889469-Japan, pubmed-meshheading:19889469-Lipids, pubmed-meshheading:19889469-Male, pubmed-meshheading:19889469-Middle Aged, pubmed-meshheading:19889469-Proteinuria, pubmed-meshheading:19889469-Remission, Spontaneous, pubmed-meshheading:19889469-Research Design, pubmed-meshheading:19889469-Young Adult
pubmed:year
2010
pubmed:articleTitle
Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT-Japan): Rationale and study design.
pubmed:affiliation
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
pubmed:publicationType
Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Multicenter Study