Linked Life Data

19889464

Source:http://linkedlifedata.com/resource/pubmed/id/19889464

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2009-11-27
pubmed:abstractText
Embryonic development is a complex process that is regulated by many cell types and signaling pathways. This review focuses on the role of NK cells and regulatory T-cells (Treg cells) in embryonic loss. Approximately 70% of uterine leukocytes until the time of mid-gestation are found to be CD16(-)CD56(bright) NK cells. This subset of NK cells, along with Treg cells, has been shown to regulate fetal development. We recently found a population of NK cells in the pregnant mouse uterus with a unique CD3(-)CD49b(+)CD25(+)Foxp3(+) phenotype. This review summarizes the studies indicating critical roles for expression of IL-10 by CD3(-)CD49b(+)CD25(+)Foxp3(+) cells and CXCR4 expression on CD16(-)CD56(bright) NK cells in preventing embryonic loss. In addition, the roles of toll-like receptors (TLRs) and CXCR4 in NK cell migration and functional modulation are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1872-7603
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
95-100
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Toll-like receptor signaling in uterine natural killer cells--role in embryonic loss.
pubmed:affiliation
Institute of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, PR China. yilinonline@gmail.com
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't