Linked Life Data

19887915

Source:http://linkedlifedata.com/resource/pubmed/id/19887915

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
2009-11-25
pubmed:abstractText
The Myc transcription factors are amongst the most potent human oncoproteins, and they fulfill essential functions during normal development. Myc heterodimerizes with a protein called Max, and it has been widely assumed that all of Myc's activities depend on this association with Max. Recent evidence calls this view into question, as Myc proteins have been shown to retain considerable biological activity when not bound to Max. The molecular nature of this Max-independent Myc activity is likely to be manifold; one aspect we have recently found not to require Max is Myc's ability to activate RNA polymerase III-dependent transcription. The discovery of these Max-independent functions changes our understanding of basic Myc biology and it may affect pharmaceutical approaches to inhibiting Myc activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1551-4005
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3848-53
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Myc's secret life without Max.
pubmed:affiliation
Universität Zürich, Zoologisches Institut, Zürich, Switzerland. gallant@zool.uzh.ch
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't