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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-3-24
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pubmed:abstractText |
Perinatal glucocorticoid treatment is associated with hypertrophic cardiomyopathy, but the cellular mechanism is controversial. An underlying interaction between glucocorticoids and the renin-angiotensin system may be important, but whether glucocorticoids modulate angiotensin II (AngII)-dependent cardiomyocyte growth responses in the neonate has not been investigated. Objectives: The major aim of this investigation was to determine whether glucocorticoids modulate the neonatal cardiomyocyte growth response to AngII. In particular we sought evidence to determine whether angiotensin II type 2 (AT(2)) receptor co-expression with angiotensin II type 1 (AT(1)) receptor is of specific importance in this modulatory function.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1661-7819
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2009 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
257-65
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pubmed:meshHeading |
pubmed-meshheading:19887855-Animals,
pubmed-meshheading:19887855-Animals, Newborn,
pubmed-meshheading:19887855-Cell Proliferation,
pubmed-meshheading:19887855-Cells, Cultured,
pubmed-meshheading:19887855-Corticosterone,
pubmed-meshheading:19887855-Dexamethasone,
pubmed-meshheading:19887855-Dose-Response Relationship, Drug,
pubmed-meshheading:19887855-Down-Regulation,
pubmed-meshheading:19887855-Drug Antagonism,
pubmed-meshheading:19887855-Gene Expression,
pubmed-meshheading:19887855-Glucocorticoids,
pubmed-meshheading:19887855-Myocytes, Cardiac,
pubmed-meshheading:19887855-Phenylephrine,
pubmed-meshheading:19887855-Rats,
pubmed-meshheading:19887855-Rats, Sprague-Dawley,
pubmed-meshheading:19887855-Receptor, Angiotensin, Type 1,
pubmed-meshheading:19887855-Receptor, Angiotensin, Type 2,
pubmed-meshheading:19887855-Transduction, Genetic
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pubmed:year |
2010
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pubmed:articleTitle |
Glucocorticoids suppress growth in neonatal cardiomyocytes co-expressing AT(2) and AT(1) angiotensin receptors.
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pubmed:affiliation |
Department of Physiology, The University of Melbourne, Parkville,Vic. 3010, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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