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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-12-17
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pubmed:abstractText |
The activation of ABL tyrosine kinase in BCR/ABL-positive chronic myelogenous leukemia (CML) leads to a diversity of biological changes related to the pathogenesis of the disease. In CML patients, we determined the expression of growth factor independence-1 (Gfi1), a transcription repressor with weak oncogenic activity. Our data demonstrated that the Gfi1 mRNA level in both the mononuclear cells and purified CD34(+) cells from CML were significantly higher as measured by quantitative real-time PCR. Using flow cytometry and Western blot, we also showed that the Gfi1 protein content was increased in CML CD34(+) cells. The expression of Gfi1 was correlated with BCR/ABL significantly. Gfi1 may be implicated in the pathogenesis of CML and can serve as a potential target for the management of the disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD34,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GFI1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/imatinib
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pubmed:status |
MEDLINE
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pubmed:issn |
1421-9662
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2009 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-5
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pubmed:meshHeading |
pubmed-meshheading:19887785-Antigens, CD34,
pubmed-meshheading:19887785-Base Sequence,
pubmed-meshheading:19887785-Blast Crisis,
pubmed-meshheading:19887785-DNA Primers,
pubmed-meshheading:19887785-DNA-Binding Proteins,
pubmed-meshheading:19887785-Gene Expression,
pubmed-meshheading:19887785-Genes, abl,
pubmed-meshheading:19887785-Hematopoietic Stem Cells,
pubmed-meshheading:19887785-Humans,
pubmed-meshheading:19887785-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:19887785-Leukemia, Myeloid, Accelerated Phase,
pubmed-meshheading:19887785-Leukemia, Myeloid, Chronic-Phase,
pubmed-meshheading:19887785-Neoplastic Stem Cells,
pubmed-meshheading:19887785-Piperazines,
pubmed-meshheading:19887785-Pyrimidines,
pubmed-meshheading:19887785-RNA, Messenger,
pubmed-meshheading:19887785-RNA, Neoplasm,
pubmed-meshheading:19887785-Stem Cell Transplantation,
pubmed-meshheading:19887785-Transcription Factors
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pubmed:year |
2010
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pubmed:articleTitle |
The growth factor independence-1 (Gfi1) is overexpressed in chronic myelogenous leukemia.
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pubmed:affiliation |
Department of Hematology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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