| pubmed-article:19887774 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19887774 | lifeskim:mentions | umls-concept:C0027022 | lld:lifeskim |
| pubmed-article:19887774 | lifeskim:mentions | umls-concept:C1504389 | lld:lifeskim |
| pubmed-article:19887774 | lifeskim:mentions | umls-concept:C1515895 | lld:lifeskim |
| pubmed-article:19887774 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19887774 | pubmed:dateCreated | 2009-11-20 | lld:pubmed |
| pubmed-article:19887774 | pubmed:abstractText | For patients with myeloid malignancies who relapse after allogeneic stem cell transplantation (allo-SCT), one salvage option is a second SCT. We retrospectively analyzed outcomes of the second allo-SCT in 25 patients who received at least 2 allografts from related/unrelated donors due to relapse of acute myeloid leukemia, myelodysplastic syndrome or myelofibrosis after the first SCT. A minority of the acute myeloid leukemia/myelodysplastic syndrome patients had reached complete hematological remission before the second SCT (6/25, 24%). Reduced conditioning strategies were performed in the majority (n = 23). Complete remission was achieved in all 21 cases with available data after the second SCT, but relapse was seen in 11/25 patients (44%). After a median follow-up of 18 months (range 6-47), 8/25 patients (32%) were still alive, and of those, 6 (24%) were in stable remission. In 9 cases mortality was associated to relapse and in 8 cases to transplant-related causes (treatment-related mortality; 8/25, 32%). In conclusion, a second SCT offers the chance of stable remission for some patients relapsing with a myeloid malignancy after a first allo-SCT, although high treatment-related mortality and relapse rates remain a problem. Efforts should concentrate on an optimization of conditioning strategies, immunosuppression and post-transplant surveillance for this specific situation. | lld:pubmed |
| pubmed-article:19887774 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19887774 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19887774 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19887774 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19887774 | pubmed:issn | 1421-9662 | lld:pubmed |
| pubmed-article:19887774 | pubmed:author | pubmed-author:KabischHartmu... | lld:pubmed |
| pubmed-article:19887774 | pubmed:author | pubmed-author:KrögerNicolau... | lld:pubmed |
| pubmed-article:19887774 | pubmed:author | pubmed-author:ZabelinaTatja... | lld:pubmed |
| pubmed-article:19887774 | pubmed:author | pubmed-author:ErttmannRudol... | lld:pubmed |
| pubmed-article:19887774 | pubmed:author | pubmed-author:AyukFrancisF | lld:pubmed |
| pubmed-article:19887774 | pubmed:author | pubmed-author:ZanderAxel... | lld:pubmed |
| pubmed-article:19887774 | pubmed:author | pubmed-author:HartwigMaiteM | lld:pubmed |
| pubmed-article:19887774 | pubmed:author | pubmed-author:BacherUlrikeU | lld:pubmed |
| pubmed-article:19887774 | pubmed:author | pubmed-author:OcheniSundayS | lld:pubmed |
| pubmed-article:19887774 | pubmed:author | pubmed-author:WiedemannBett... | lld:pubmed |
| pubmed-article:19887774 | pubmed:author | pubmed-author:AsenovaSvetla... | lld:pubmed |
| pubmed-article:19887774 | pubmed:copyrightInfo | Copyright 2009 S. Karger AG, Basel. | lld:pubmed |
| pubmed-article:19887774 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19887774 | pubmed:volume | 122 | lld:pubmed |
| pubmed-article:19887774 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19887774 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19887774 | pubmed:pagination | 185-92 | lld:pubmed |
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| pubmed-article:19887774 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19887774 | pubmed:articleTitle | Second allogeneic stem cell transplantation in myeloid malignancies. | lld:pubmed |
| pubmed-article:19887774 | pubmed:affiliation | Clinic for Stem Cell Transplantation, University Cancer Center Hamburg, Hamburg, Germany. | lld:pubmed |
| pubmed-article:19887774 | pubmed:publicationType | Journal Article | lld:pubmed |
