Source:http://linkedlifedata.com/resource/pubmed/id/19887774
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2009-11-20
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| pubmed:abstractText |
For patients with myeloid malignancies who relapse after allogeneic stem cell transplantation (allo-SCT), one salvage option is a second SCT. We retrospectively analyzed outcomes of the second allo-SCT in 25 patients who received at least 2 allografts from related/unrelated donors due to relapse of acute myeloid leukemia, myelodysplastic syndrome or myelofibrosis after the first SCT. A minority of the acute myeloid leukemia/myelodysplastic syndrome patients had reached complete hematological remission before the second SCT (6/25, 24%). Reduced conditioning strategies were performed in the majority (n = 23). Complete remission was achieved in all 21 cases with available data after the second SCT, but relapse was seen in 11/25 patients (44%). After a median follow-up of 18 months (range 6-47), 8/25 patients (32%) were still alive, and of those, 6 (24%) were in stable remission. In 9 cases mortality was associated to relapse and in 8 cases to transplant-related causes (treatment-related mortality; 8/25, 32%). In conclusion, a second SCT offers the chance of stable remission for some patients relapsing with a myeloid malignancy after a first allo-SCT, although high treatment-related mortality and relapse rates remain a problem. Efforts should concentrate on an optimization of conditioning strategies, immunosuppression and post-transplant surveillance for this specific situation.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1421-9662
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| pubmed:author |
pubmed-author:AsenovaSvetlanaS,
pubmed-author:AyukFrancisF,
pubmed-author:BacherUlrikeU,
pubmed-author:ErttmannRudolfR,
pubmed-author:HartwigMaiteM,
pubmed-author:KabischHartmutH,
pubmed-author:KrögerNicolausN,
pubmed-author:OcheniSundayS,
pubmed-author:WiedemannBettinaB,
pubmed-author:ZabelinaTatjanaT,
pubmed-author:ZanderAxel RolfAR
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| pubmed:copyrightInfo |
Copyright 2009 S. Karger AG, Basel.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
122
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
185-92
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| pubmed:meshHeading |
pubmed-meshheading:19887774-Adolescent,
pubmed-meshheading:19887774-Adult,
pubmed-meshheading:19887774-Bone Marrow Transplantation,
pubmed-meshheading:19887774-Child, Preschool,
pubmed-meshheading:19887774-Female,
pubmed-meshheading:19887774-Graft Survival,
pubmed-meshheading:19887774-Graft vs Host Disease,
pubmed-meshheading:19887774-Humans,
pubmed-meshheading:19887774-Leukemia, Myeloid, Acute,
pubmed-meshheading:19887774-Leukemia, Myelomonocytic, Juvenile,
pubmed-meshheading:19887774-Male,
pubmed-meshheading:19887774-Middle Aged,
pubmed-meshheading:19887774-Myelodysplastic Syndromes,
pubmed-meshheading:19887774-Peripheral Blood Stem Cell Transplantation,
pubmed-meshheading:19887774-Polycythemia,
pubmed-meshheading:19887774-Primary Myelofibrosis,
pubmed-meshheading:19887774-Recurrence,
pubmed-meshheading:19887774-Reoperation,
pubmed-meshheading:19887774-Retrospective Studies,
pubmed-meshheading:19887774-Salvage Therapy,
pubmed-meshheading:19887774-Transplantation, Homologous,
pubmed-meshheading:19887774-Transplantation Conditioning,
pubmed-meshheading:19887774-Young Adult
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| pubmed:year |
2009
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| pubmed:articleTitle |
Second allogeneic stem cell transplantation in myeloid malignancies.
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| pubmed:affiliation |
Clinic for Stem Cell Transplantation, University Cancer Center Hamburg, Hamburg, Germany.
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| pubmed:publicationType |
Journal Article
|