Source:http://linkedlifedata.com/resource/pubmed/id/19886737
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2009-11-5
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| pubmed:abstractText |
Thymoma is a thymic epithelial neoplasm which induces T cell development. However, the frequency of mature CD4(+) T cells in thymomas is lower than in normal thymi. Recently, CD4/CD8 lineage commitment has been elucidated in animal model. The zinc finger transcription factor Th-POK is a critical factor to CD4(+) T cell development in CD4/CD8 lineage commitment, whereas CD8(+) T cell development requires the transcription factor Runx3. These factors antagonize in CD4/CD8 lineage commitment. In this study, we examined Th-POK and Runx3 mRNA expression in the T cell subsets of human normal thymus and thymoma. A quantitative reverse transcriptase-polymerase chain reaction examination revealed that Th-POK expression in normal thymi was higher in the CD4(+)CD8(-) subset than in the CD4(+)CD8(+) and CD4(-)CD8(+) subsets. In thymomas, Th-POK expression in the CD4(+)CD8(-) subset was significantly lower than that in normal thymi, and was significantly correlated with the proportion of CD3(+) cells in the CD4(+)CD8(-) subset. However, Th-POK expressions of the CD3(+)CD4(+)CD8(+) and CD3(+)CD4(+)CD8(-) subsets were not impaired in thymomas compared to normal thymi. These results suggest that thymoma neoplastic epithelial cells can induce Th-POK expression similarly to the normal thymic epithelial cells. In addition, there was no significant difference in Runx3 expression between normal thymi and thymomas. Therefore, CD4/CD8 lineage commitment dependent on Th-POK and Runx3 system seems to be working even in the neoplastic environment formed by human thymomas.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Core Binding Factor Alpha 3 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Runx3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/ZBTB7B protein, human
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1607-842X
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
42
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
653-60
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| pubmed:meshHeading |
pubmed-meshheading:19886737-Adult,
pubmed-meshheading:19886737-Aged,
pubmed-meshheading:19886737-Antigens, CD3,
pubmed-meshheading:19886737-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19886737-CD8-Positive T-Lymphocytes,
pubmed-meshheading:19886737-Cell Count,
pubmed-meshheading:19886737-Cell Differentiation,
pubmed-meshheading:19886737-Core Binding Factor Alpha 3 Subunit,
pubmed-meshheading:19886737-DNA-Binding Proteins,
pubmed-meshheading:19886737-Female,
pubmed-meshheading:19886737-Gene Expression Regulation,
pubmed-meshheading:19886737-Humans,
pubmed-meshheading:19886737-Male,
pubmed-meshheading:19886737-Middle Aged,
pubmed-meshheading:19886737-T-Lymphocyte Subsets,
pubmed-meshheading:19886737-T-Lymphocytes,
pubmed-meshheading:19886737-Thymoma,
pubmed-meshheading:19886737-Thymus Gland,
pubmed-meshheading:19886737-Transcription Factors
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| pubmed:year |
2009
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| pubmed:articleTitle |
Regulation of Th-POK and Runx3 in T cell development in human thymoma.
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| pubmed:affiliation |
Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
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| pubmed:publicationType |
Journal Article
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