|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2010-2-5
|
|
pubmed:abstractText |
Colorectal cancers (CRCs) may be classified according to underlying genetic and epigenetic changes including microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP). However the relevance of these molecular characteristics, which are being increasingly used to guide adjuvant therapy, has not been defined for metastatic disease. Since adjunct chemotherapy is designed to prevent or target metastases, molecular characteristics of metastatic disease are relevant. This study evaluates molecular differences between primary colorectal cancers and matched lymph node (LN) metastases.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1534-4681
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
17
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
425-31
|
|
pubmed:meshHeading |
pubmed-meshheading:19885699-Adult,
pubmed-meshheading:19885699-Aged,
pubmed-meshheading:19885699-Aged, 80 and over,
pubmed-meshheading:19885699-Chromosomal Instability,
pubmed-meshheading:19885699-Colorectal Neoplasms,
pubmed-meshheading:19885699-CpG Islands,
pubmed-meshheading:19885699-Female,
pubmed-meshheading:19885699-Follow-Up Studies,
pubmed-meshheading:19885699-Humans,
pubmed-meshheading:19885699-Lymphatic Metastasis,
pubmed-meshheading:19885699-Male,
pubmed-meshheading:19885699-Middle Aged,
pubmed-meshheading:19885699-Neoplasm Staging,
pubmed-meshheading:19885699-Phenotype,
pubmed-meshheading:19885699-Prognosis,
pubmed-meshheading:19885699-Prospective Studies,
pubmed-meshheading:19885699-Tumor Markers, Biological
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Stage III colorectal cancer: molecular disparity between primary cancers and lymph node metastases.
|
|
pubmed:affiliation |
Department of Colorectal Surgery, Cleveland Clinic, Cleveland, OH, USA. craigatcase@yahoo.com
|
|
pubmed:publicationType |
Journal Article
|
