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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-12-16
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pubmed:abstractText |
Phosphorodiamidate morpholino oligomers (PMOs) are uncharged DNA analogues that can inhibit bacterial growth by a gene-specific, antisense mechanism. Attaching cationic peptides to PMOs enables efficient penetration through the Gram-negative outer membrane. We hypothesized that cationic groups attached directly to the PMO would obviate the need to attach peptides.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1460-2091
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
98-106
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19884121-Animals,
pubmed-meshheading:19884121-Anti-Bacterial Agents,
pubmed-meshheading:19884121-Blood,
pubmed-meshheading:19884121-Escherichia coli,
pubmed-meshheading:19884121-Escherichia coli Infections,
pubmed-meshheading:19884121-Female,
pubmed-meshheading:19884121-Humans,
pubmed-meshheading:19884121-Injections, Subcutaneous,
pubmed-meshheading:19884121-Mice,
pubmed-meshheading:19884121-Mice, Inbred BALB C,
pubmed-meshheading:19884121-Microbial Sensitivity Tests,
pubmed-meshheading:19884121-Morpholines,
pubmed-meshheading:19884121-Morpholinos,
pubmed-meshheading:19884121-Peritonitis,
pubmed-meshheading:19884121-Survival Analysis
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pubmed:year |
2010
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pubmed:articleTitle |
Cationic phosphorodiamidate morpholino oligomers efficiently prevent growth of Escherichia coli in vitro and in vivo.
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pubmed:affiliation |
AVI BioPharma, Inc., Corvallis, OR 97333, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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