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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2009-11-30
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pubmed:abstractText |
Chemical examination of the secondary metabolites of a marine Saccharomonospora sp., isolated from marine sediments collected at the mouth of the La Jolla Submarine Canyon, yielded the unprecedented alkaloid lodopyridone (1). The low proton-to-carbon ratio of 1 precluded structure elucidation by NMR spectroscopic methods, thus the structure was defined by X-ray crystallography. Lodopyridone is cytotoxic to HCT-116 human colon cancer cells with IC(50) = 3.6 microM.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1523-7052
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
3
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5422-4
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pubmed:dateRevised |
2010-12-30
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pubmed:meshHeading |
pubmed-meshheading:19883103-Actinobacteria,
pubmed-meshheading:19883103-Alkaloids,
pubmed-meshheading:19883103-Antineoplastic Agents,
pubmed-meshheading:19883103-Crystallography, X-Ray,
pubmed-meshheading:19883103-Drug Screening Assays, Antitumor,
pubmed-meshheading:19883103-HCT116 Cells,
pubmed-meshheading:19883103-Humans,
pubmed-meshheading:19883103-Marine Biology,
pubmed-meshheading:19883103-Methicillin-Resistant Staphylococcus aureus,
pubmed-meshheading:19883103-Microbial Sensitivity Tests,
pubmed-meshheading:19883103-Molecular Conformation,
pubmed-meshheading:19883103-Molecular Structure,
pubmed-meshheading:19883103-Nuclear Magnetic Resonance, Biomolecular
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pubmed:year |
2009
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pubmed:articleTitle |
Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete.
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pubmed:affiliation |
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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