rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
6
|
pubmed:dateCreated |
2010-2-11
|
pubmed:abstractText |
The germinal center (GC) reaction has a pivotal function in human B-cell lymphomagenesis. Genetic aberrations occurring during somatic hypermutation and class switch recombination deregulate key factors controlling B-cell physiology and proliferation. Several human lymphoma entities are characterized by a constitutive GC phenotype and ongoing somatic hypermutation, but the molecular basis for this phenomenon is only partly understood. We have investigated the reasons for a constitutive GC-like program in Burkitt's lymphoma cells. Here, overexpression of c-Myc leads to a centroblast phenotype, promotes high constitutive expression of the key GC factors Bcl-6, E2A and activation-induced cytidine deaminase and contributes to proliferation and somatic hypermutation. Our findings elucidate how the activity of a pivotal transcription factor may freeze B-cell lymphoma cells in a constitutive GC-like state that is even maintained at an extrafollicular location.
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pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
1476-5594
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:day |
11
|
pubmed:volume |
29
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
888-97
|
pubmed:meshHeading |
pubmed-meshheading:19881537-Animals,
pubmed-meshheading:19881537-B-Lymphocytes,
pubmed-meshheading:19881537-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:19881537-Burkitt Lymphoma,
pubmed-meshheading:19881537-Cell Line, Tumor,
pubmed-meshheading:19881537-Cytidine Deaminase,
pubmed-meshheading:19881537-DNA-Binding Proteins,
pubmed-meshheading:19881537-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19881537-Germinal Center,
pubmed-meshheading:19881537-Humans,
pubmed-meshheading:19881537-Phenotype,
pubmed-meshheading:19881537-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:19881537-Somatic Hypermutation, Immunoglobulin
|
pubmed:year |
2010
|
pubmed:articleTitle |
c-Myc overexpression promotes a germinal center-like program in Burkitt's lymphoma.
|
pubmed:affiliation |
Institute of Clinical Molecular Biology, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|