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rdf:type |
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lifeskim:mentions |
umls-concept:C0005773,
umls-concept:C0013018,
umls-concept:C0035020,
umls-concept:C0150369,
umls-concept:C0332324,
umls-concept:C0333678,
umls-concept:C1332710,
umls-concept:C1504389,
umls-concept:C1511790,
umls-concept:C1515895,
umls-concept:C1947906
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pubmed:issue |
11
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pubmed:dateCreated |
2009-11-2
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pubmed:abstractText |
Analysis of donor chimerism is an important diagnostic tool to assess the risk of relapse after allogeneic stem cell transplantation, especially in patients lacking a specific marker suitable for monitoring of minimal residual disease. We prospectively investigated the predictive value of donor chimerism analyses in sorted CD34(+) peripheral blood cells in 90 patients with acute leukemia and myelodysplastic syndrome. The cumulative incidence of relapse after four years was significantly increased in cases with decreasing or incomplete CD34(+) donor chimerism (57% vs. 18%, p=0.0001). Multivariate analysis confirmed decreasing CD34(+) donor chimerism as an independent predictor of relapse and inferior survival. The interval between a decrease of CD34(+) chimerism of less than 80% and hematologic relapse was 61 days (range 0-567). Monitoring of CD34(+) donor chimerism in the peripheral blood allows prediction of imminent relapse after allogeneic stem cell transplantation even when a disease-specific marker is lacking.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880783-10373073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880783-11236950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880783-11320898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880783-11753621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880783-12406915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880783-15201854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880783-15345597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880783-15470491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880783-15772700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880783-16110027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880783-16620971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880783-17488876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880783-17581611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880783-17611565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880783-18000811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880783-19100523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880783-1958479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880783-9160487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880783-9808551
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1592-8721
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pubmed:author |
pubmed-author:BornhäuserMartinM,
pubmed-author:BrendelCorneliaC,
pubmed-author:BugGesineG,
pubmed-author:EhningerGerhardG,
pubmed-author:FauserAxel AAA,
pubmed-author:IllmerThomasT,
pubmed-author:KianiAlexanderA,
pubmed-author:KiehlMichael GMG,
pubmed-author:KleinStefanS,
pubmed-author:LutterbeckKarinK,
pubmed-author:MartinHansH,
pubmed-author:MohrBrigitteB,
pubmed-author:OelschlaegelUtaU,
pubmed-author:PlatzbeckerUweU,
pubmed-author:SchaichMarkusM,
pubmed-author:ScheteligJohannesJ,
pubmed-author:TheuserCatrinC,
pubmed-author:ThiedeChristianC
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pubmed:issnType |
Electronic
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1613-7
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pubmed:dateRevised |
2010-9-28
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pubmed:meshHeading |
pubmed-meshheading:19880783-Antigens, CD34,
pubmed-meshheading:19880783-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:19880783-Humans,
pubmed-meshheading:19880783-Leukemia,
pubmed-meshheading:19880783-Molecular Diagnostic Techniques,
pubmed-meshheading:19880783-Neoplasm, Residual,
pubmed-meshheading:19880783-Prospective Studies,
pubmed-meshheading:19880783-Recurrence,
pubmed-meshheading:19880783-Survival Analysis,
pubmed-meshheading:19880783-Transplantation, Homologous,
pubmed-meshheading:19880783-Transplantation Chimera
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pubmed:year |
2009
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pubmed:articleTitle |
Monitoring of donor chimerism in sorted CD34+ peripheral blood cells allows the sensitive detection of imminent relapse after allogeneic stem cell transplantation.
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pubmed:affiliation |
Medizinische Klinik und Poliklinik I, University Hospital, Dresden, Germany. martin.bornhaeuser@uniklinikum-dresden.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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