Linked Life Data

19879912

Source:http://linkedlifedata.com/resource/pubmed/id/19879912

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SubjectPredicateObjectContext
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pubmed-article:19879912pubmed:abstractTextThe CD45 77C>G transversion (rs17612648) in exon A of the CD45 gene has been reported to be associated with the development of various autoimmune diseases. Because Hashimoto's thyroiditis (HT) is a typical autoimmune disease, we performed a study to determine the association of the 77C>G transversion with susceptibility to HT. We enrolled 170 patients and 230 healthy individuals in the study. The 77C>G transversion was genotyped by polymerase chain reaction-allele specific restriction enzyme analysis (PCR-ASRA). We found four patients and six control individuals who carried the 77C>G transversion in a heterozygous form. No homozygous individual was detected in patients with HT or control population. The frequency of the 77G allele in patients was 1.2%, which did not significantly differ from 1.3% in controls (p = 0.871). Our data did not reveal any association between CD45 77C>G transversion and susceptibility to HT in a German population.lld:pubmed
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pubmed-article:19879912pubmed:authorpubmed-author:ThudeHHlld:pubmed
pubmed-article:19879912pubmed:authorpubmed-author:WeissenbornSSlld:pubmed
pubmed-article:19879912pubmed:copyrightInfoCopyright 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.lld:pubmed
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pubmed-article:19879912pubmed:volume71lld:pubmed
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pubmed-article:19879912pubmed:pagination220-3lld:pubmed
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pubmed-article:19879912pubmed:year2010lld:pubmed
pubmed-article:19879912pubmed:articleTitleNo association between transmembrane protein-tyrosine-phosphatase receptor type C (CD45) exon A 77C>G transversion and Hashimoto's thyroiditis in a German population.lld:pubmed
pubmed-article:19879912pubmed:affiliationUniversity Clinic Hamburg-Eppendorf, Transplantation Centre, Department of Hepatobiliary and Transplant Surgery, Hamburg, Germany. h.thude@uke.delld:pubmed
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