Source:http://linkedlifedata.com/resource/pubmed/id/19879912
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2010-2-1
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| pubmed:abstractText |
The CD45 77C>G transversion (rs17612648) in exon A of the CD45 gene has been reported to be associated with the development of various autoimmune diseases. Because Hashimoto's thyroiditis (HT) is a typical autoimmune disease, we performed a study to determine the association of the 77C>G transversion with susceptibility to HT. We enrolled 170 patients and 230 healthy individuals in the study. The 77C>G transversion was genotyped by polymerase chain reaction-allele specific restriction enzyme analysis (PCR-ASRA). We found four patients and six control individuals who carried the 77C>G transversion in a heterozygous form. No homozygous individual was detected in patients with HT or control population. The frequency of the 77G allele in patients was 1.2%, which did not significantly differ from 1.3% in controls (p = 0.871). Our data did not reveal any association between CD45 77C>G transversion and susceptibility to HT in a German population.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1879-1166
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
71
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
220-3
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| pubmed:meshHeading |
pubmed-meshheading:19879912-Adolescent,
pubmed-meshheading:19879912-Adult,
pubmed-meshheading:19879912-Aged,
pubmed-meshheading:19879912-Aged, 80 and over,
pubmed-meshheading:19879912-Antigens, CD45,
pubmed-meshheading:19879912-Child,
pubmed-meshheading:19879912-Exons,
pubmed-meshheading:19879912-Female,
pubmed-meshheading:19879912-Gene Frequency,
pubmed-meshheading:19879912-Genetic Predisposition to Disease,
pubmed-meshheading:19879912-Genotype,
pubmed-meshheading:19879912-Germany,
pubmed-meshheading:19879912-Hashimoto Disease,
pubmed-meshheading:19879912-Humans,
pubmed-meshheading:19879912-Male,
pubmed-meshheading:19879912-Middle Aged,
pubmed-meshheading:19879912-Polymerase Chain Reaction,
pubmed-meshheading:19879912-Polymorphism, Single Nucleotide,
pubmed-meshheading:19879912-Young Adult
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| pubmed:year |
2010
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| pubmed:articleTitle |
No association between transmembrane protein-tyrosine-phosphatase receptor type C (CD45) exon A 77C>G transversion and Hashimoto's thyroiditis in a German population.
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| pubmed:affiliation |
University Clinic Hamburg-Eppendorf, Transplantation Centre, Department of Hepatobiliary and Transplant Surgery, Hamburg, Germany. h.thude@uke.de
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| pubmed:publicationType |
Journal Article
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