Linked Life Data

19879662

Source:http://linkedlifedata.com/resource/pubmed/id/19879662

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-2-1
pubmed:abstractText
The fluorotelomer alcohols (FTOHs) have been detected in the aquatic environment and shown potential estrogenic activity, but the effects on fish reproduction remain unknown. In the present study, 4-month-old zebrafish were exposed to different concentrations of 8:2 FTOH (0, 10, 30, 90, 270microg/L) for 4 weeks, and the impact on reproduction was investigated. The plasma testosterone (T) and estradiol (E2) levels were significantly increased in the females, while T and E2 levels were decreased and increased in the males, respectively. The average number of eggs spawned and sperm production were reduced upon exposure to the chemical, which also resulted in thinning of eggshell, and reduced protein content and egg diameter. Histological examination showed promotion of oocyte maturation and retarded spermiation in female and male fish, respectively. The gene transcription of follicle-stimulating hormone beta (FSHbeta) and luteinizing hormone beta (LHbeta) in the pituitary were up- and down-regulated in female and male fish, respectively. Up-regulation of vitellogenin (VTG1) and zona pellucida protein 2 (ZP2a) gene transcription was observed in the males, indicating estrogenic activity. However, down-regulation of gene transcription of VTG1 and ZP2a was measured in the females, associated with decreased fecundity. In addition, exposure of adult zebrafish to 8:2 FTOH caused reduced hatching rates in the offspring. The results demonstrated that waterborne exposure to 8:2 FTOH caused disruption of sex hormone biosynthesis and impaired reproduction in adult zebrafish, ultimately resulting in decreased hatching rates in the offspring.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1879-1514
pubmed:author
pubmed:copyrightInfo
2009 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
21
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
70-6
pubmed:meshHeading
pubmed-meshheading:19879662-Animals, pubmed-meshheading:19879662-Endocrine Disruptors, pubmed-meshheading:19879662-Estradiol, pubmed-meshheading:19879662-Female, pubmed-meshheading:19879662-Fertility, pubmed-meshheading:19879662-Follicle Stimulating Hormone, beta Subunit, pubmed-meshheading:19879662-Gene Expression Regulation, pubmed-meshheading:19879662-Hydrocarbons, Fluorinated, pubmed-meshheading:19879662-Luteinizing Hormone, pubmed-meshheading:19879662-Male, pubmed-meshheading:19879662-Oocytes, pubmed-meshheading:19879662-Pituitary Gland, pubmed-meshheading:19879662-Reproduction, pubmed-meshheading:19879662-Sperm Maturation, pubmed-meshheading:19879662-Testosterone, pubmed-meshheading:19879662-Water Pollutants, Chemical, pubmed-meshheading:19879662-Zebrafish, pubmed-meshheading:19879662-Zebrafish Proteins
pubmed:year
2010
pubmed:articleTitle
Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol.
pubmed:affiliation
Institute of Hydrobiology, Wuhan, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't