|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0016441,
umls-concept:C0019904,
umls-concept:C0030705,
umls-concept:C0205214,
umls-concept:C0302583,
umls-concept:C0332281,
umls-concept:C0439793,
umls-concept:C0752046,
umls-concept:C1332424,
umls-concept:C1384665,
umls-concept:C2828008
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2010-2-3
|
|
pubmed:abstractText |
It is now generally admitted that penetrance of the common HFE p.C282Y/p.C282Y genotype is incomplete, and identification of modifier genes is the concern of a growing number of research projects. We recently identified a significant association between pretherapeutic serum ferritin level and the common rs235756 single nucleotide polymorphism (SNP) of the BMP2 gene region. Our results further suggested an interactive effect between the BMP2 rs235756 SNP and the rs16827043 SNP in HJV, with a small additive effect of the rs4901474 SNP in BMP4.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1096-0961
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2009 Elsevier Inc. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
15
|
|
pubmed:volume |
44
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
34-7
|
|
pubmed:meshHeading |
pubmed-meshheading:19879168-Adult,
pubmed-meshheading:19879168-Alcohol Drinking,
pubmed-meshheading:19879168-Amino Acid Substitution,
pubmed-meshheading:19879168-Biological Markers,
pubmed-meshheading:19879168-Bone Morphogenetic Protein 2,
pubmed-meshheading:19879168-Cohort Studies,
pubmed-meshheading:19879168-Female,
pubmed-meshheading:19879168-Ferritins,
pubmed-meshheading:19879168-Follow-Up Studies,
pubmed-meshheading:19879168-France,
pubmed-meshheading:19879168-Gene Frequency,
pubmed-meshheading:19879168-Genetic Association Studies,
pubmed-meshheading:19879168-Hemochromatosis,
pubmed-meshheading:19879168-Histocompatibility Antigens Class I,
pubmed-meshheading:19879168-Homozygote,
pubmed-meshheading:19879168-Humans,
pubmed-meshheading:19879168-Iron,
pubmed-meshheading:19879168-Male,
pubmed-meshheading:19879168-Membrane Proteins,
pubmed-meshheading:19879168-Middle Aged,
pubmed-meshheading:19879168-Penetrance,
pubmed-meshheading:19879168-Phlebotomy,
pubmed-meshheading:19879168-Polymorphism, Single Nucleotide,
pubmed-meshheading:19879168-Severity of Illness Index
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
A common SNP near BMP2 is associated with severity of the iron burden in HFE p.C282Y homozygous patients: a follow-up study.
|
|
pubmed:affiliation |
IRD - UR010, Paris, France.
|
|
pubmed:publicationType |
Journal Article
|
