Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-11-12
pubmed:abstractText
Lung cancer remains a leading cause of cancer death among both men and women in the United States. Treatment modalities available for this malignancy are inadequate and thus new drugs with improved pharmacological profiles and superior therapeutic indices are being continually explored. Noscapinoids constitute an emerging class of anticancer agents that bind tubulin but do not significantly alter the monomer/polymer ratio of tubulin. EM011, a rationally-designed member of this class of non-toxic agents, is more potent than the lead molecule, noscapine.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-10561264, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-10941904, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-11710735, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-12615954, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-12644580, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-12879125, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-12898598, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-1515985, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-15264992, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-15720262, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-15930332, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-16023594, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-16023598, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-16282340, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-16585205, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-16780803, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-16985071, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-17406391, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-17440101, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-18025274, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-18316614, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-18347163, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-18451153, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-18656424, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-18698017, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-2359136, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-7753834, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-7912516, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-8156541, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-8358726, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-9000560, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-9256286, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-9465062, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-9584191, http://linkedlifedata.com/resource/pubmed/commentcorrection/19878573-9804855
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins, http://linkedlifedata.com/resource/pubmed/chemical/BIRC5 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3, http://linkedlifedata.com/resource/pubmed/chemical/Dioxoles, http://linkedlifedata.com/resource/pubmed/chemical/EM011 compound, http://linkedlifedata.com/resource/pubmed/chemical/Inhibitor of Apoptosis Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Isoquinolines, http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Poly(ADP-ribose) Polymerases, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering, http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein
pubmed:status
MEDLINE
pubmed:issn
1476-4598
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
93
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:19878573-Apoptosis, pubmed-meshheading:19878573-Apoptosis Regulatory Proteins, pubmed-meshheading:19878573-Carcinoma, Non-Small-Cell Lung, pubmed-meshheading:19878573-Caspase 3, pubmed-meshheading:19878573-Cell Line, Tumor, pubmed-meshheading:19878573-Cell Proliferation, pubmed-meshheading:19878573-DNA Fragmentation, pubmed-meshheading:19878573-Dioxoles, pubmed-meshheading:19878573-Down-Regulation, pubmed-meshheading:19878573-Drug Screening Assays, Antitumor, pubmed-meshheading:19878573-Enzyme Activation, pubmed-meshheading:19878573-G2 Phase, pubmed-meshheading:19878573-Humans, pubmed-meshheading:19878573-Inhibitor of Apoptosis Proteins, pubmed-meshheading:19878573-Isoquinolines, pubmed-meshheading:19878573-Lung Neoplasms, pubmed-meshheading:19878573-Microtubule-Associated Proteins, pubmed-meshheading:19878573-Mitosis, pubmed-meshheading:19878573-Mitotic Spindle Apparatus, pubmed-meshheading:19878573-Poly(ADP-ribose) Polymerases, pubmed-meshheading:19878573-RNA, Small Interfering, pubmed-meshheading:19878573-bcl-2-Associated X Protein
pubmed:year
2009
pubmed:articleTitle
EM011 activates a survivin-dependent apoptotic program in human non-small cell lung cancer cells.
pubmed:affiliation
Department of Biology, Georgia State University, Atlanta, GA-30303, USA. pkarna@gsu.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural