Linked Life Data

1987846

Source:http://linkedlifedata.com/resource/pubmed/id/1987846

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-2-20
pubmed:abstractText
The topical application of acidified (pH 1.2) bile acids to acid-peptic-secreting gastric mucosa increases mucosal blood flow, an important protective event because, when it is blunted, gross mucosal injury occurs. The mediators of this response are unknown. The current study examined the potential roles of luminal pH, luminal bile acid concentration, and, indirectly, endogenous prostaglandin generation in groups of dogs prepared with ex vivo chambered wedges of proximal gastric wall. Parameters evaluated included H+ fluxes, mucosal blood flow using radiolabeled microspheres, and the severity of gross mucosal injury induced at high and low intraluminal pH (7 and 1.2), at differing concentrations of bile acid (0, 2.5, 5.0 mM), in the presence of indomethacin pretreatment with or without concomitant close intra-arterial infusion of prostacyclin. The results indicate that topical bile acids increase mucosal blood flow in proportion to their capacity to induce H+ loss. This response is blunted (but not ablated) by indomethacin, resulting in gross mucosal injury, effects that are reversed by prostacyclin infusion. Thus, in large part, endogenous prostaglandins are its likely mediators.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0002-9610
pubmed:author
pubmed:issnType
Print
pubmed:volume
161
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
126-30
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Mediators of bile acid-induced alterations in gastric mucosal blood flow.
pubmed:affiliation
Department of Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.
pubmed:publicationType
Journal Article