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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-1-4
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pubmed:abstractText |
Micro-RNA (miR) are increasingly recognized as critical regulators of tissue-specific patterns of gene expression. CD4+ T cells lacking miR-155, for example, exhibit bias towards Th2 differentiation, indicating that the absence of individual miR could alter CD4+ T-cell differentiation. We now show that miR-155 is induced upon T-cell activation and that it promotes Th1 differentiation when over-expressed in activated CD4+ T cells. Antagonism of miR-155 leads to induction of IFN-gamma receptor alpha-chain (IFN-gammaRalpha), and a functional miR-155 target site is identified within the 3' untranslated region of IFN-gammaRalpha. These results identify IFN-gammaRalpha as a second miR-155 target in T cells and suggest that miR-155 contributes to Th1 differentiation in CD4+ T cells by inhibiting IFN-gamma signaling.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-10725704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-11015439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-11696328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-11752460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-12006974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-12426003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-12661002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-14605368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-14657504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-15738415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-15867090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-15944707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-16009718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-16086853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-16258535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-17382377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-17418783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-17438277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-17463289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-17463290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-17923094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-17925868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-18369135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-19144316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-19234151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-2967332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-7502050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-7618088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877012-8674125
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1521-4141
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
225-31
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:19877012-Animals,
pubmed-meshheading:19877012-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19877012-Cell Differentiation,
pubmed-meshheading:19877012-Cells, Cultured,
pubmed-meshheading:19877012-Interferon-gamma,
pubmed-meshheading:19877012-Mice,
pubmed-meshheading:19877012-Mice, Inbred BALB C,
pubmed-meshheading:19877012-Mice, Inbred C57BL,
pubmed-meshheading:19877012-MicroRNAs,
pubmed-meshheading:19877012-Receptor, Interferon alpha-beta,
pubmed-meshheading:19877012-Signal Transduction
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pubmed:year |
2010
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pubmed:articleTitle |
Micro-RNA-155 inhibits IFN-gamma signaling in CD4+ T cells.
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pubmed:affiliation |
Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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