Source:http://linkedlifedata.com/resource/pubmed/id/19875987
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
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pubmed:dateCreated |
2010-6-28
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pubmed:abstractText |
Steatosis in obese nonalcoholic fatty liver disease (NAFLD) patients is a clinicopathological condition associated with depletion of n-3 polyunsaturated fatty acids (PUFA), a feature that may be related to PUFA desaturation. Liver Delta-6 and Delta-5 desaturase (Delta-6D and Delta-5D) activities, homeostasis model assessment of insulin resistance (HOMA(IR)), and ferric reducing ability of plasma (FRAP) were evaluated in 13 obese patients who underwent subtotal gastrectomy with gastro-jejunal anastomosis in Roux-en-Y and 15 nonobese patients who underwent laparoscopic cholecystectomy (controls). Liver Delta-6D and Delta-5D activities in obese patients were 87% and 66% lower than controls (P < 0.001), respectively, with a 62% diminution in the Delta-6D/Delta-5D activity ratio (P < 0.02). Delta-6D inversely correlated with both HOMA(IR) (r = -0.70, P < 0.0001) and oxidative stress assessed as the reciprocal value of FRAP (r = -0.40, P < 0.05). Delta-5D negatively correlated with HOMA(IR) (r = -0.48, P < 0.01) but not with FRAP(-1) (r = -0.13, not significant). In conclusion, liver PUFA desaturation is diminished in obese NAFLD patients, in association with underlying insulin resistance and oxidative stress, which may play a role in altering lipid metabolism favoring fatty infiltration.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acid Desaturases,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Linoleoyl-CoA Desaturase,
http://linkedlifedata.com/resource/pubmed/chemical/delta-5 fatty acid desaturase
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1930-7381
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1460-3
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pubmed:meshHeading |
pubmed-meshheading:19875987-Adult,
pubmed-meshheading:19875987-Cholecystectomy, Laparoscopic,
pubmed-meshheading:19875987-Enzyme Activation,
pubmed-meshheading:19875987-Fatty Acid Desaturases,
pubmed-meshheading:19875987-Fatty Acids, Unsaturated,
pubmed-meshheading:19875987-Fatty Liver,
pubmed-meshheading:19875987-Female,
pubmed-meshheading:19875987-Gastric Bypass,
pubmed-meshheading:19875987-Homeostasis,
pubmed-meshheading:19875987-Humans,
pubmed-meshheading:19875987-Insulin Resistance,
pubmed-meshheading:19875987-Linoleoyl-CoA Desaturase,
pubmed-meshheading:19875987-Lipid Metabolism,
pubmed-meshheading:19875987-Liver,
pubmed-meshheading:19875987-Male,
pubmed-meshheading:19875987-Obesity,
pubmed-meshheading:19875987-Oxidative Stress
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pubmed:year |
2010
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pubmed:articleTitle |
Decreased liver fatty acid delta-6 and delta-5 desaturase activity in obese patients.
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pubmed:affiliation |
Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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