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pubmed-article:19875832pubmed:issue11lld:pubmed
pubmed-article:19875832pubmed:dateCreated2009-10-30lld:pubmed
pubmed-article:19875832pubmed:abstractTextThe sensitivity and specificity of rapid HIV-1 tests may be altered during pregnancy and postpartum. We conducted a study to determine the prevalence and correlates of false-positive Abbott Determine and false-negative Uni-Gold rapid HIV-1 test results among antenatal and postnatal mothers attending a primary care clinic in Nairobi, Kenya. Mothers were tested for HIV-1 using Abbott Determine and non-reactive results were considered HIV-1 antibody negative. Reactive samples by Determine were re-tested by Uni-Gold. Vironostika HIV-1 and Uni-FORM II Enzyme-linked immunosorbent assays were used to confirm samples that had positive Abbott Determine and negative Uni-Gold. Among 2311 women who accepted HIV-1 testing, 1238 (54%) were tested antenatally and 1073 (46%) were tested postnatally. Of tested women, 274 (12%) women were reactive by Abbott Determine and on retesting with Uni-Gold 30 (11%) had indeterminate results. The prevalence of indeterminate results was significantly higher in antenatal women than in postnatal women (2% versus 1%, P = 0.03). In conclusion, indeterminate rapid HIV-1 test results are more common in the antenatal period and appropriate safeguards to confirm HIV-1 infection status should be implemented in antenatal programmes.lld:pubmed
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pubmed-article:19875832pubmed:authorpubmed-author:JohnFFlld:pubmed
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pubmed-article:19875832pubmed:authorpubmed-author:KinuthiaJJlld:pubmed
pubmed-article:19875832pubmed:authorpubmed-author:MatemoDDlld:pubmed
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pubmed-article:19875832pubmed:volume20lld:pubmed
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pubmed-article:19875832pubmed:year2009lld:pubmed
pubmed-article:19875832pubmed:articleTitleIndeterminate rapid HIV-1 test results among antenatal and postnatal mothers.lld:pubmed
pubmed-article:19875832pubmed:affiliationDepartment of Obstetric and Gynaecology, University of Nairobi, Kenya. daniel.matemo@uonbi.ac.kelld:pubmed
pubmed-article:19875832pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19875832pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:19875832pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:19875832pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed