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rdf:type |
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lifeskim:mentions |
umls-concept:C0016030,
umls-concept:C0033684,
umls-concept:C0441889,
umls-concept:C0598086,
umls-concept:C0598388,
umls-concept:C0599894,
umls-concept:C1156236,
umls-concept:C1415887,
umls-concept:C1419040,
umls-concept:C1420433,
umls-concept:C1424666,
umls-concept:C1538465,
umls-concept:C2586323
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|
pubmed:issue |
3
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pubmed:dateCreated |
2010-2-26
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pubmed:abstractText |
Although antiproliferative drugs have been used to prevent scarring after filtration surgery in patients with glaucoma, there are complications associated with their use. In the present study, the authors investigated whether small interfering RNA (siRNA)-mediated gene silencing of Skp2 can be used to increase p27(kip1) level and inhibit cell proliferation in rabbit Tenon's capsule fibroblast (rTF).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1552-5783
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1475-82
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pubmed:meshHeading |
pubmed-meshheading:19875654-Animals,
pubmed-meshheading:19875654-Blotting, Western,
pubmed-meshheading:19875654-Cell Culture Techniques,
pubmed-meshheading:19875654-Cell Proliferation,
pubmed-meshheading:19875654-Cell Survival,
pubmed-meshheading:19875654-Connective Tissue Cells,
pubmed-meshheading:19875654-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:19875654-Fibroblasts,
pubmed-meshheading:19875654-Gene Silencing,
pubmed-meshheading:19875654-Immunohistochemistry,
pubmed-meshheading:19875654-Male,
pubmed-meshheading:19875654-Microscopy, Fluorescence,
pubmed-meshheading:19875654-Plasmids,
pubmed-meshheading:19875654-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:19875654-RNA, Small Interfering,
pubmed-meshheading:19875654-Rabbits,
pubmed-meshheading:19875654-S-Phase Kinase-Associated Proteins,
pubmed-meshheading:19875654-Trabeculectomy,
pubmed-meshheading:19875654-Transfection,
pubmed-meshheading:19875654-Vimentin
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pubmed:year |
2010
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pubmed:articleTitle |
Inhibition of cell proliferation of Tenon's capsule fibroblast by S-phase kinase-interacting protein 2 targeting SiRNA through increasing p27 protein level.
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pubmed:affiliation |
Department of Ophthalmology, First Clinical College, Harbin Medical University, Harbin, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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