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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-2-20
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pubmed:abstractText |
The reported inability to establish long-term T-cell lines from the blood of cutaneous T-cell lymphoma patients with circulating neoplastic T cells has hindered the development of an in vitro system to investigate Sézary syndrome. We have established a rapidly proliferating T-cell line from the peripheral blood of a patient with Sézary syndrome, which expresses a mature helper T-cell phenotype and contains cytogenetic abnormalities and T-cell receptor gene rearrangements identical to those in the patient's blood. The method of establishment and characteristics of this line are described.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Probes,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-202X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
31-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1987293-Aged,
pubmed-meshheading:1987293-Antibodies, Monoclonal,
pubmed-meshheading:1987293-Antigens, CD,
pubmed-meshheading:1987293-Antigens, CD4,
pubmed-meshheading:1987293-Antigens, Surface,
pubmed-meshheading:1987293-Cell Line,
pubmed-meshheading:1987293-Culture Techniques,
pubmed-meshheading:1987293-DNA, Neoplasm,
pubmed-meshheading:1987293-DNA Probes,
pubmed-meshheading:1987293-DNA Replication,
pubmed-meshheading:1987293-Female,
pubmed-meshheading:1987293-Humans,
pubmed-meshheading:1987293-Interleukin-2,
pubmed-meshheading:1987293-Lymphocyte Activation,
pubmed-meshheading:1987293-Phenotype,
pubmed-meshheading:1987293-Sezary Syndrome,
pubmed-meshheading:1987293-Skin Neoplasms,
pubmed-meshheading:1987293-T-Lymphocytes
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pubmed:year |
1991
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pubmed:articleTitle |
A clonal CD4-positive T-cell line established from the blood of a patient with Sézary syndrome.
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pubmed:affiliation |
Wistar Institute, Philadelphia, PA 19104.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports,
Research Support, Non-U.S. Gov't
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