Source:http://linkedlifedata.com/resource/pubmed/id/19867211
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2010-6-23
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| pubmed:abstractText |
The H antigen was mapped out by immunofluorescence in human tissues (including those of fetuses from 15 cm crown-heel length) from individuals of the various groups within the ABO system, both secretors and non-secretors. The distribution of the antigen can be summarized under the following headings: Cell walls of endothelium: present throughout the cardiovascular system; Cell walls of stratified epithelia: in skin, non-cornifying squamous stratified membranes, transitional epithelia; Mucus: occurring wherever the latter is produced in secretor individuals and confined to a few special topographical areas in non-secretors; Secretions and excretions: the pancreatic and sudoriferous (independent of secretor status), and mammary and uterine (governed by the secretor makeup) all contain it. The distribution of the H antigen is most fully represented in tissues of group O. It follows an over-all universal pattern, characteristically modified in non-secretors, equally valid for antigens A and B described in a preceding study. Within this pattern, in tissues of the non-O groups, the complement of the H substance in its various forms wanes in a manner consistent with the hypothesis that it serves as a substrate for the A(1), A(2), B genes, exerting their action with different degrees of efficiency. The secretor:non-secretor phenomena can be most simply interpreted by viewing the non-secretor, recessive gene (in the homozygous, ss condition) as inhibiting the production of some of the water-soluble forms of the blood group substances. Since the gene was never found responsible for dissociation of the H and A, B antigens its inhibitory action is thought to be wrought at the point of formation of the basic H substance or its precursor.
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| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19867211-13163552,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19867211-13710639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19867211-13735038,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19867211-14918471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19867211-14935090,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19867211-19870436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19867211-19871103
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0022-1007
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
115
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
977-96
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| pubmed:dateRevised |
2010-9-28
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| pubmed:year |
1962
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| pubmed:articleTitle |
THE HISTOLOGICAL DISTRIBUTION OF THE BLOOD GROUP SUBSTANCES IN MAN AS DISCLOSED BY IMMUNOFLUORESCENCE : II. THE H ANTIGEN AND ITS RELATION TO A AND B ANTIGENS.
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| pubmed:affiliation |
Departments of Pathology, Harvard Medical School, and the Boston Lying-In Hospital, Boston.
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| pubmed:publicationType |
Journal Article
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