19866343

Source:http://linkedlifedata.com/resource/pubmed/id/19866343

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0004561, umls-concept:C0024141, umls-concept:C0030705, umls-concept:C0443264, umls-concept:C1527233, umls-concept:C1533691
pubmed:issue	6
pubmed:dateCreated	2010-1-21
pubmed:abstractText	Aberrant signaling within and between B and T cells, considered to be central in systemic lupus erythematosus (SLE), could depend on enhanced CD40-CD154 activation. As a result, autoreactive B cells, normally anergic, differentiate and secrete antibodies attacking several normal tissues. Thus restorating B cell homeostasis might help control this disease. In this study, two facets of SLE B cells were investigated, namely their in vitro response to CD40-CD154 and the effect of treatment with human immunoglobulins for intravenous use (IVIg).
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0114365
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation, http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins, Intravenous
pubmed:status	MEDLINE
pubmed:issn	1661-4917
pubmed:author	pubmed-author:BoireGillesG, pubmed-author:CôtéSergeS, pubmed-author:DussaultNathalieN, pubmed-author:JacquesAnnieA, pubmed-author:NéronSoniaS, pubmed-author:RacineClaudiaC, pubmed-author:de Brum-FernandesArtur JAJ
pubmed:issnType	Electronic
pubmed:volume	57
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	447-58
pubmed:meshHeading	pubmed-meshheading:19866343-Adolescent, pubmed-meshheading:19866343-Adult, pubmed-meshheading:19866343-Aged, pubmed-meshheading:19866343-Aged, 80 and over, pubmed-meshheading:19866343-Antigens, CD, pubmed-meshheading:19866343-Antigens, Differentiation, pubmed-meshheading:19866343-B-Lymphocytes, pubmed-meshheading:19866343-Cell Differentiation, pubmed-meshheading:19866343-Cell Proliferation, pubmed-meshheading:19866343-Cell Separation, pubmed-meshheading:19866343-Cells, Cultured, pubmed-meshheading:19866343-Female, pubmed-meshheading:19866343-Flow Cytometry, pubmed-meshheading:19866343-Humans, pubmed-meshheading:19866343-Immunoglobulins, Intravenous, pubmed-meshheading:19866343-Immunotherapy, pubmed-meshheading:19866343-Lupus Erythematosus, Systemic, pubmed-meshheading:19866343-Lymphocyte Activation, pubmed-meshheading:19866343-Male, pubmed-meshheading:19866343-Middle Aged
pubmed:articleTitle	CD40-activated B cells from patients with systemic lupus erythematosus can be modulated by therapeutic immunoglobulins in vitro.
pubmed:affiliation	Recherche et développement, Héma-Québec, Ingénierie cellulaire, 1070, avenue des Sciences-de-la-vie, Québec, QC G1V 5C3, Canada. sonia.neron@hema-quebec.qc.ca
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't