Linked Life Data

19865713

Source:http://linkedlifedata.com/resource/pubmed/id/19865713

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
2009-10-29
pubmed:abstractText
Various human illnesses, including several types of cancer and infectious diseases, are related to changes in the cellular redox homeostasis. During the last decade, several approaches have been explored which employ such disturbed redox balances for the benefit of therapy. Compounds able to modulate the intracellular redox state of cells have been developed, which effectively, yet also selectively, appear to kill cancer cells and a range of pathogenic microorganisms. Among the various agents employed, certain redox catalysts have shown considerable promise since they are non-toxic on their own yet develop an effective, often selective cytotoxicity in the presence of the 'correct' intracellular redox partners. Aminoalkylation, amide coupling and multicomponent reactions are suitable synthetic methods to generate a vast number of such multifunctional catalysts, which are chemically diverse and, depending on their structure, exhibit various interesting biological activities.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1477-0539
pubmed:author
pubmed:issnType
Electronic
pubmed:day
21
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4753-62
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Exploring synthetic avenues for the effective synthesis of selenium- and tellurium-containing multifunctional redox agents.
pubmed:affiliation
Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, PO Box 151150, D-66123, Saarbruecken, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't