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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-12-23
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pubmed:abstractText |
The Step Study was a randomized trial to reduce HIV infection through vaccination with an adenovirus type 5 (Ad5)-based gag/pol/nef construct; analysis following early cessation of the trial revealed an excess of HIV seroconversion in Ad5 seropositive men. This led to the suggestion that the Ad based vector may boost the number of CD4 chemokine receptor 5 (CCR5) T cells, target cells for HIV infection.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jan
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pubmed:issn |
1473-5571
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
16
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
205-10
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pubmed:meshHeading |
pubmed-meshheading:19864932-Adenoviruses, Human,
pubmed-meshheading:19864932-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19864932-Genetic Vectors,
pubmed-meshheading:19864932-HIV Infections,
pubmed-meshheading:19864932-HIV Seropositivity,
pubmed-meshheading:19864932-HIV-1,
pubmed-meshheading:19864932-Humans,
pubmed-meshheading:19864932-Immunologic Memory,
pubmed-meshheading:19864932-Immunophenotyping,
pubmed-meshheading:19864932-Integrins,
pubmed-meshheading:19864932-Phenotype,
pubmed-meshheading:19864932-Receptors, CCR5
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pubmed:year |
2010
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pubmed:articleTitle |
Adenovirus vector-specific T cells demonstrate a unique memory phenotype with high proliferative potential and coexpression of CCR5 and integrin alpha4beta7.
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pubmed:affiliation |
University of Birmingham, Birmingham, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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