Linked Life Data

19864659

Source:http://linkedlifedata.com/resource/pubmed/id/19864659

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2009-10-29
pubmed:abstractText
Polymorphisms in genes encoding amyloid beta-peptide (A beta)-degrading enzymes neprilysin (NEP) and insulin-degrading enzyme (IDE) individually affect the susceptibility to Alzheimer disease (AD) among the Finnish population. Here we show that a combination of risk genotypes for NEP and IDE genes leads to a higher susceptibility to AD. Individuals with the combination of risk genotypes for NEP and IDE conferred a threefold higher susceptibility to AD when compared with individuals not carrying these genotypes. Although no significant interaction was observed between NEP and IDE genes, these data suggest that NEP and IDE exhibit an additive risk effect in AD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1468-330X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1268-70
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Combined risk effects of IDE and NEP gene variants on Alzheimer disease.
pubmed:affiliation
Department of Neurology, Kuopio University and University Hospital, PO Box 1627, 70211 Kuopio, Finland. saila.vepsalainen@uku.fi
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't