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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-12-16
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pubmed:abstractText |
We have previously observed that TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) induces acquired TRAIL resistance by increasing Akt phosphorylation and Bcl-xL expression. In this study, we report that Src, c-Cbl, and PI3K are involved in the phosphorylation of Akt during TRAIL treatment. Data from immunoprecipitation and immunoblotting assay reveal that Src interacts with c-Cbl and PI3K. Data from immune complex kinase assay demonstrate that Src can directly phosphorylate c-Cbl and PI3K p85 subunit protein. Data from gene knockdown experiments with an RNA interference (RNAi) technique show that c-Cbl is involved in the interaction between Src and PI3K p85 during TRAIL treatment, playing an important role in TRAIL-induced Akt phosphorylation. Taken together, c-Cbl may act as a mediator to regulate the Src-PI3K-Akt signal transduction pathway during TRAIL treatment.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-10022120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-10075741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-10359702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-10485710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-10676810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-10811865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-10958661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-11087752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-11448952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-11994282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-12094235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-12486874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-12668516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-14523545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-15120327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-15289937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-15389633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-15505410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-15684417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-15963759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-16751802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-16785986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-17110373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-18276109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-19713527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-8550620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-8650270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-8663110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-9414268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-9444956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-9721089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19861161-9990038
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1873-3913
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
377-85
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pubmed:dateRevised |
2011-7-25
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pubmed:meshHeading |
pubmed-meshheading:19861161-Caspase 8,
pubmed-meshheading:19861161-Cell Line, Tumor,
pubmed-meshheading:19861161-Humans,
pubmed-meshheading:19861161-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:19861161-Phosphorylation,
pubmed-meshheading:19861161-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:19861161-Proto-Oncogene Proteins c-cbl,
pubmed-meshheading:19861161-Proto-Oncogene Proteins pp60(c-src),
pubmed-meshheading:19861161-RNA, Small Interfering,
pubmed-meshheading:19861161-Signal Transduction,
pubmed-meshheading:19861161-TNF-Related Apoptosis-Inducing Ligand
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pubmed:year |
2010
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pubmed:articleTitle |
c-Cbl acts as a mediator of Src-induced activation of the PI3K-Akt signal transduction pathway during TRAIL treatment.
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pubmed:affiliation |
Institute for Cancer Research, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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