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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-5-31
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pubmed:abstractText |
Our previous studies illustrated that berberine inhibited adipogenesis in murine-derived 3T3-L1 preadipocytes and human white preadipocytes. In this study, the effects of berberine on the adipogenesis of high-fat diet-induced obesity (FD) or normal diet (ND) mice and possible transcriptional impact are investigated. The results demonstrated that in FD mice, berberine reduced mouse weight gain and food intake and serum glucose, triglyceride, and total cholesterol levels accompanied with a down-regulation of PPARgamma expression and an up-regulation of GATA-3 expression. Berberine had no adverse effects on ND mice. These encouraging findings suggest that berberine has excellent pharmacological potential to prevent obesity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1873-6971
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pubmed:author |
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pubmed:copyrightInfo |
Published by Elsevier B.V.
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pubmed:issnType |
Electronic
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
358-66
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pubmed:meshHeading |
pubmed-meshheading:19861153-3T3-L1 Cells,
pubmed-meshheading:19861153-Adipogenesis,
pubmed-meshheading:19861153-Animals,
pubmed-meshheading:19861153-Berberine,
pubmed-meshheading:19861153-Blood Glucose,
pubmed-meshheading:19861153-Cholesterol,
pubmed-meshheading:19861153-Diet, Atherogenic,
pubmed-meshheading:19861153-Dietary Fats,
pubmed-meshheading:19861153-Disease Models, Animal,
pubmed-meshheading:19861153-Energy Intake,
pubmed-meshheading:19861153-GATA3 Transcription Factor,
pubmed-meshheading:19861153-Gene Expression,
pubmed-meshheading:19861153-Hypolipidemic Agents,
pubmed-meshheading:19861153-Male,
pubmed-meshheading:19861153-Mice,
pubmed-meshheading:19861153-Mice, Inbred C57BL,
pubmed-meshheading:19861153-Obesity,
pubmed-meshheading:19861153-PPAR gamma,
pubmed-meshheading:19861153-Phytotherapy,
pubmed-meshheading:19861153-Plant Extracts,
pubmed-meshheading:19861153-Triglycerides,
pubmed-meshheading:19861153-Weight Gain
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pubmed:year |
2010
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pubmed:articleTitle |
Berberine inhibits adipogenesis in high-fat diet-induced obesity mice.
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pubmed:affiliation |
Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD 57007, USA.
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pubmed:publicationType |
Journal Article
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