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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-10-27
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pubmed:abstractText |
This study was carried out to investigate whether dietary vitamin E and ferulic acid (FA) can exert possible interactions on preventions of hypercholesterolemia and atherogenic lesion formation in C57BL/65 apolipoprotein E-deficient (apo E(-/-)) mice. Four-week-old male apo E(-/-) mice were randomly divided into three groups and given one of three types of Western diets with various amounts of vitamin E (0.02%, 0%, or 0.2%) for 15 weeks. FA was added to vitamin E-free Western diet and vitamin E-rich Western diet at the 0.02% level. The plasma total cholesterol concentration was significantly lowered when FA was added to the vitamin E-free and vitamin E-rich Western diet as compared to the normal vitamin E Western diet (0.02% vitamin E), and this was accompanied with a decreased hepatic acyl-coenzyme A:cholesterol acyltransferase activity. The hepatic and erythrocyte thiobarbituric acid-reactive substances levels were significantly lowered when FA was added to the vitamin E-rich Western diet, which was attributable to increased activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and paraoxonase. Accordingly, vitamin E and/or FA are beneficial for prevention of hypercholesterolemia and atherogenesis in apo E(-/-) mice. In particular, dietary FA exhibited an anti-atherosclerotic property, and this effect was synergistically enhanced with the vitamin E supplement.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acyl Coenzyme A,
http://linkedlifedata.com/resource/pubmed/chemical/Anticholesteremic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/Coumaric Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Sterol O-Acyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Thiobarbiturates,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin E,
http://linkedlifedata.com/resource/pubmed/chemical/ferulic acid,
http://linkedlifedata.com/resource/pubmed/chemical/thiobarbituric acid
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1557-7600
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
996-1003
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pubmed:meshHeading |
pubmed-meshheading:19857062-Acyl Coenzyme A,
pubmed-meshheading:19857062-Animals,
pubmed-meshheading:19857062-Anticholesteremic Agents,
pubmed-meshheading:19857062-Antioxidants,
pubmed-meshheading:19857062-Apolipoproteins E,
pubmed-meshheading:19857062-Arteriosclerosis,
pubmed-meshheading:19857062-Coumaric Acids,
pubmed-meshheading:19857062-Diet,
pubmed-meshheading:19857062-Drug Therapy, Combination,
pubmed-meshheading:19857062-Hypercholesterolemia,
pubmed-meshheading:19857062-Lipids,
pubmed-meshheading:19857062-Male,
pubmed-meshheading:19857062-Mice,
pubmed-meshheading:19857062-Mice, Inbred C57BL,
pubmed-meshheading:19857062-Mice, Knockout,
pubmed-meshheading:19857062-Phytotherapy,
pubmed-meshheading:19857062-Plant Extracts,
pubmed-meshheading:19857062-Sterol O-Acyltransferase,
pubmed-meshheading:19857062-Thiobarbiturates,
pubmed-meshheading:19857062-Vitamin E
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pubmed:year |
2009
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pubmed:articleTitle |
Actions of ferulic acid and vitamin E on prevention of hypercholesterolemia and atherogenic lesion formation in apolipoprotein E-deficient mice.
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pubmed:affiliation |
Department of Food Science and Nutrition, Seoul, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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