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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-1-21
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pubmed:abstractText |
Defects in pancreatic beta cell turnover are implicated in the pathogenesis of type 2 diabetes by genetic markers for diabetes. Decreased beta cell neogenesis could contribute to diabetes. The longevity and turnover of human beta cells is unknown; in rodents <1 year old, a half-life of 30 days is estimated. Intracellular lipofuscin body (LB) accumulation is a hallmark of ageing in neurons. To estimate the lifespan of human beta cells, we measured beta cell LB accumulation in individuals aged 1-81 years.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1432-0428
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pubmed:author |
pubmed-author:ClarkAA,
pubmed-author:CnopII,
pubmed-author:CnopMM,
pubmed-author:GrayD W GDW,
pubmed-author:GunterJ HJH,
pubmed-author:HansenB CBC,
pubmed-author:HoppaM BMB,
pubmed-author:HughesS JSJ,
pubmed-author:Igoillo-EsteveMM,
pubmed-author:JohnsonP R VPR,
pubmed-author:MorrisJ FJF,
pubmed-author:Pipeleers-MarichalMM,
pubmed-author:SayyedFF,
pubmed-author:WallsG VGV,
pubmed-author:de KoningE J PEJ,
pubmed-author:van de LaarLL
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pubmed:issnType |
Electronic
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
321-30
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pubmed:meshHeading |
pubmed-meshheading:19855953-Adult,
pubmed-meshheading:19855953-Age Distribution,
pubmed-meshheading:19855953-Aging,
pubmed-meshheading:19855953-Animals,
pubmed-meshheading:19855953-Biological Markers,
pubmed-meshheading:19855953-Cause of Death,
pubmed-meshheading:19855953-Cell Division,
pubmed-meshheading:19855953-Diabetes Mellitus, Type 2,
pubmed-meshheading:19855953-Humans,
pubmed-meshheading:19855953-Insulin-Secreting Cells,
pubmed-meshheading:19855953-Lipofuscin,
pubmed-meshheading:19855953-Macaca mulatta,
pubmed-meshheading:19855953-Mice,
pubmed-meshheading:19855953-Mice, Inbred C57BL,
pubmed-meshheading:19855953-Models, Theoretical,
pubmed-meshheading:19855953-Pancreas,
pubmed-meshheading:19855953-Tissue Donors
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pubmed:year |
2010
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pubmed:articleTitle |
The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation.
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pubmed:affiliation |
Laboratory of Experimental Medicine and Division of Endocrinology, Université Libre de Bruxelles, Brussels, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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