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rdf:type |
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lifeskim:mentions |
umls-concept:C0003467,
umls-concept:C0011570,
umls-concept:C0017337,
umls-concept:C0027893,
umls-concept:C0087111,
umls-concept:C0849912,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1709694,
umls-concept:C2911692
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pubmed:issue |
5
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pubmed:dateCreated |
2010-3-29
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pubmed:abstractText |
Neuropeptide Y (NPY) has been found to play a role in the pathomechanism of both anxiety and depression. Thus, NPY is a promising candidate in the investigation of the clinical phenotype of "anxious depression". Five NPY gene variants were investigated for an influence on antidepressant treatment response in a sample of 256 patients with depression. Additionally, NPY gene impact on amygdala activation during facial emotion processing was analyzed in a subsample of 35 depressed patients. Particularly in anxious depression, the less active NPY rs16147 -399C allele conferred slow response after 2weeks and failure to achieve remission after four weeks of treatment. The rs16147 C allele was further associated with stronger bilateral amygdala activation in response to threatening faces in an allele-dose fashion. The present results point towards a possible influence of functional NPY gene variation on antidepressant treatment response in anxious depression, potentially conveyed by altered emotional processing.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1873-7862
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|
pubmed:author |
pubmed-author:AroltVolkerV,
pubmed-author:BauerJochenJ,
pubmed-author:BauneBernhard TBT,
pubmed-author:DannlowskiUdoU,
pubmed-author:DeckertJürgenJ,
pubmed-author:DomschkeKatharinaK,
pubmed-author:HeindelWalterW,
pubmed-author:HohoffChristaC,
pubmed-author:KugelHaraldH,
pubmed-author:OhrmannPatriciaP,
pubmed-author:SuslowThomasT,
pubmed-author:ZwanzgerPeterP
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pubmed:copyrightInfo |
2009 Elsevier B.V. and ECNP. All rights reserved.
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pubmed:issnType |
Electronic
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
301-9
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pubmed:meshHeading |
pubmed-meshheading:19854625-Adult,
pubmed-meshheading:19854625-Aged,
pubmed-meshheading:19854625-Alleles,
pubmed-meshheading:19854625-Amygdala,
pubmed-meshheading:19854625-Antidepressive Agents,
pubmed-meshheading:19854625-Anxiety,
pubmed-meshheading:19854625-Brain Mapping,
pubmed-meshheading:19854625-Chi-Square Distribution,
pubmed-meshheading:19854625-Depression,
pubmed-meshheading:19854625-Depressive Disorder,
pubmed-meshheading:19854625-Emotions,
pubmed-meshheading:19854625-Female,
pubmed-meshheading:19854625-Gene Frequency,
pubmed-meshheading:19854625-Genetic Association Studies,
pubmed-meshheading:19854625-Genotype,
pubmed-meshheading:19854625-Humans,
pubmed-meshheading:19854625-Image Processing, Computer-Assisted,
pubmed-meshheading:19854625-Magnetic Resonance Imaging,
pubmed-meshheading:19854625-Male,
pubmed-meshheading:19854625-Middle Aged,
pubmed-meshheading:19854625-Neuropeptide Y,
pubmed-meshheading:19854625-Pharmacogenetics,
pubmed-meshheading:19854625-Polymorphism, Single Nucleotide,
pubmed-meshheading:19854625-Treatment Outcome
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pubmed:year |
2010
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|
pubmed:articleTitle |
Neuropeptide Y (NPY) gene: Impact on emotional processing and treatment response in anxious depression.
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|
pubmed:affiliation |
Dept. of Psychiatry, University of Muenster, Germany. katharina.domschke@ukmuenster.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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