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| pubmed-article:19854131 | lifeskim:mentions | umls-concept:C0684063 | lld:lifeskim |
| pubmed-article:19854131 | lifeskim:mentions | umls-concept:C0024501 | lld:lifeskim |
| pubmed-article:19854131 | lifeskim:mentions | umls-concept:C1823135 | lld:lifeskim |
| pubmed-article:19854131 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:19854131 | lifeskim:mentions | umls-concept:C1428560 | lld:lifeskim |
| pubmed-article:19854131 | lifeskim:mentions | umls-concept:C1824460 | lld:lifeskim |
| pubmed-article:19854131 | lifeskim:mentions | umls-concept:C0721534 | lld:lifeskim |
| pubmed-article:19854131 | lifeskim:mentions | umls-concept:C0444930 | lld:lifeskim |
| pubmed-article:19854131 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19854131 | pubmed:dateCreated | 2009-10-26 | lld:pubmed |
| pubmed-article:19854131 | pubmed:abstractText | Orthologs of the yeast telomere protein Stn1 are present in plants, but other components of the Cdc13/Stn1/Ten1 (CST) complex have only been found in fungi. Here we report the identification of conserved telomere maintenance component 1 (CTC1) in plants and vertebrates. CTC1 encodes an approximately 140 kDa telomere-associated protein predicted to contain multiple OB-fold domains. Arabidopsis mutants null for CTC1 display a severe telomere deprotection phenotype accompanied by a rapid onset of developmental defects and sterility. Telomeric and subtelomeric tracts are dramatically eroded, and chromosome ends exhibit increased G overhangs, recombination, and end-to-end fusions. AtCTC1 both physically and genetically interacts with AtSTN1. Depletion of human CTC1 by RNAi triggers a DNA damage response, chromatin bridges, increased G overhangs, and sporadic telomere loss. These data indicate that CTC1 participates in telomere maintenance in diverse species and that a CST-like complex is required for telomere integrity in multicellular organisms. | lld:pubmed |
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| pubmed-article:19854131 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19854131 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19854131 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19854131 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19854131 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19854131 | pubmed:issn | 1097-4164 | lld:pubmed |
| pubmed-article:19854131 | pubmed:author | pubmed-author:ShippenDoroth... | lld:pubmed |
| pubmed-article:19854131 | pubmed:author | pubmed-author:PriceCarolyn... | lld:pubmed |
| pubmed-article:19854131 | pubmed:author | pubmed-author:LambJonathan... | lld:pubmed |
| pubmed-article:19854131 | pubmed:author | pubmed-author:SurovtsevaYul... | lld:pubmed |
| pubmed-article:19854131 | pubmed:author | pubmed-author:HeacockMichel... | lld:pubmed |
| pubmed-article:19854131 | pubmed:author | pubmed-author:SongXiangyuX | lld:pubmed |
| pubmed-article:19854131 | pubmed:author | pubmed-author:ChurikovDmitr... | lld:pubmed |
| pubmed-article:19854131 | pubmed:author | pubmed-author:BoltzKara AKA | lld:pubmed |
| pubmed-article:19854131 | pubmed:author | pubmed-author:LeehyKatherin... | lld:pubmed |
| pubmed-article:19854131 | pubmed:author | pubmed-author:WarringtonRos... | lld:pubmed |
| pubmed-article:19854131 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19854131 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:19854131 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:19854131 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19854131 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19854131 | pubmed:pagination | 207-18 | lld:pubmed |
| pubmed-article:19854131 | pubmed:dateRevised | 2011-6-15 | lld:pubmed |
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| pubmed-article:19854131 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19854131 | pubmed:articleTitle | Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes. | lld:pubmed |
| pubmed-article:19854131 | pubmed:affiliation | Department of Biochemistry and Biophysics, Texas A&M University, 2128 TAMU, College Station, TX 77843-2128, USA. | lld:pubmed |
| pubmed-article:19854131 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19854131 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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