| pubmed-article:19854051 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19854051 | lifeskim:mentions | umls-concept:C1334306 | lld:lifeskim |
| pubmed-article:19854051 | lifeskim:mentions | umls-concept:C2267115 | lld:lifeskim |
| pubmed-article:19854051 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:19854051 | lifeskim:mentions | umls-concept:C1554184 | lld:lifeskim |
| pubmed-article:19854051 | lifeskim:mentions | umls-concept:C0205549 | lld:lifeskim |
| pubmed-article:19854051 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:19854051 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:19854051 | pubmed:dateCreated | 2009-11-5 | lld:pubmed |
| pubmed-article:19854051 | pubmed:abstractText | A series of N-(4-(6,7-disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides targeting c-Met and VEGFR2 tyrosine kinases was designed and synthesized. The compounds were potent against these two enzymes with IC(50) values in the low nanomolar range in vitro, possessed favorable pharmacokinetic profiles and showed high efficacy in vivo in several human tumor xenograft models in mice. | lld:pubmed |
| pubmed-article:19854051 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19854051 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19854051 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19854051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19854051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19854051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19854051 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19854051 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19854051 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:WangJamesJ | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:BeaulieuNorma... | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:RobertMarie-F... | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:NguyenHannahH | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:BeaulieuCarol... | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:BestermanJeff... | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:ClaridgeSteph... | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:VaisburgArkad... | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:LefebvreSylva... | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:DupontIsabell... | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:ZhanLijieL | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:RaeppelFranck... | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:DézielRobertR | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:ZhouNancyN | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:RaeppelStépha... | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:GaudetteFrédé... | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:RahilJubrailJ | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:SaavedraOscar... | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:Robert... | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:Ste-CroixHélè... | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:ChuteIanI | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:DubayMarjaM | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:IsakovicLjubo... | lld:pubmed |
| pubmed-article:19854051 | pubmed:author | pubmed-author:MannionMichae... | lld:pubmed |
| pubmed-article:19854051 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19854051 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19854051 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:19854051 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19854051 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19854051 | pubmed:pagination | 6552-6 | lld:pubmed |
| pubmed-article:19854051 | pubmed:meshHeading | pubmed-meshheading:19854051... | lld:pubmed |
| pubmed-article:19854051 | pubmed:meshHeading | pubmed-meshheading:19854051... | lld:pubmed |
| pubmed-article:19854051 | pubmed:meshHeading | pubmed-meshheading:19854051... | lld:pubmed |
| pubmed-article:19854051 | pubmed:meshHeading | pubmed-meshheading:19854051... | lld:pubmed |
| pubmed-article:19854051 | pubmed:meshHeading | pubmed-meshheading:19854051... | lld:pubmed |
| pubmed-article:19854051 | pubmed:meshHeading | pubmed-meshheading:19854051... | lld:pubmed |
| pubmed-article:19854051 | pubmed:meshHeading | pubmed-meshheading:19854051... | lld:pubmed |
| pubmed-article:19854051 | pubmed:meshHeading | pubmed-meshheading:19854051... | lld:pubmed |
| pubmed-article:19854051 | pubmed:meshHeading | pubmed-meshheading:19854051... | lld:pubmed |
| pubmed-article:19854051 | pubmed:meshHeading | pubmed-meshheading:19854051... | lld:pubmed |
| pubmed-article:19854051 | pubmed:meshHeading | pubmed-meshheading:19854051... | lld:pubmed |
| pubmed-article:19854051 | pubmed:meshHeading | pubmed-meshheading:19854051... | lld:pubmed |
| pubmed-article:19854051 | pubmed:meshHeading | pubmed-meshheading:19854051... | lld:pubmed |
| pubmed-article:19854051 | pubmed:meshHeading | pubmed-meshheading:19854051... | lld:pubmed |
| pubmed-article:19854051 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19854051 | pubmed:articleTitle | N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors. | lld:pubmed |
| pubmed-article:19854051 | pubmed:affiliation | Department of Medicinal Chemistry, MethylGene Inc, Montréal, QC, Canada. | lld:pubmed |
| pubmed-article:19854051 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:19854051 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19854051 | lld:pubmed |
