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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2009-11-5
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pubmed:abstractText |
A series of N-(4-(6,7-disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides targeting c-Met and VEGFR2 tyrosine kinases was designed and synthesized. The compounds were potent against these two enzymes with IC(50) values in the low nanomolar range in vitro, possessed favorable pharmacokinetic profiles and showed high efficacy in vivo in several human tumor xenograft models in mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:BeaulieuCaroleC,
pubmed-author:BeaulieuNormandN,
pubmed-author:BestermanJeffrey MJM,
pubmed-author:ChuteIanI,
pubmed-author:ClaridgeStephenS,
pubmed-author:DézielRobertR,
pubmed-author:DubayMarjaM,
pubmed-author:DupontIsabelleI,
pubmed-author:GaudetteFrédéricF,
pubmed-author:IsakovicLjubomirL,
pubmed-author:LefebvreSylvainS,
pubmed-author:MannionMichaelM,
pubmed-author:NguyenHannahH,
pubmed-author:RaeppelFranckF,
pubmed-author:RaeppelStéphaneS,
pubmed-author:RahilJubrailJ,
pubmed-author:Robert MacleodAA,
pubmed-author:RobertMarie-FranceMF,
pubmed-author:SaavedraOscarO,
pubmed-author:Ste-CroixHélèneH,
pubmed-author:VaisburgArkadiiA,
pubmed-author:WangJamesJ,
pubmed-author:ZhanLijieL,
pubmed-author:ZhouNancyN
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6552-6
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pubmed:meshHeading |
pubmed-meshheading:19854051-Animals,
pubmed-meshheading:19854051-Antineoplastic Agents,
pubmed-meshheading:19854051-Cell Proliferation,
pubmed-meshheading:19854051-Dose-Response Relationship, Drug,
pubmed-meshheading:19854051-Drug Design,
pubmed-meshheading:19854051-Drug Screening Assays, Antitumor,
pubmed-meshheading:19854051-Humans,
pubmed-meshheading:19854051-Mice,
pubmed-meshheading:19854051-Models, Molecular,
pubmed-meshheading:19854051-Molecular Structure,
pubmed-meshheading:19854051-Protein Kinase Inhibitors,
pubmed-meshheading:19854051-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:19854051-Stereoisomerism,
pubmed-meshheading:19854051-Structure-Activity Relationship
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pubmed:year |
2009
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pubmed:articleTitle |
N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.
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pubmed:affiliation |
Department of Medicinal Chemistry, MethylGene Inc, Montréal, QC, Canada.
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pubmed:publicationType |
Journal Article
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