|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003402,
umls-concept:C0021469,
umls-concept:C0023837,
umls-concept:C0037733,
umls-concept:C0205296,
umls-concept:C0220781,
umls-concept:C0220825,
umls-concept:C0441655,
umls-concept:C1262902,
umls-concept:C1452252,
umls-concept:C1880022,
umls-concept:C1883254
|
|
pubmed:issue |
23
|
|
pubmed:dateCreated |
2009-11-9
|
|
pubmed:abstractText |
A series of 2'-hydroxy-chalcones and their oxidative cyclization products, aurones, have been synthesized and tested for their antioxidant and lipoxygenase inhibitory activity. The natural product aureusidin (31) was synthesized in high yield by a new approach. An extensive structure-relationship study was performed and revealed that several chalcones and aurones possess an appealing pharmacological profile combining high antioxidant and lipid peroxidation activity with potent soybean LOX inhibition.
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|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1464-3391
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
1
|
|
pubmed:volume |
17
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
8073-85
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity.
|
|
pubmed:affiliation |
National Technical University of Athens, School of Chemical Engineering, Department of Chemical Sciences, Laboratory of Organic Chemistry, Zografou Campus, 15773 Athens, Greece. adetsi@chemeng.ntua.gr
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
