Linked Life Data

19853397

Source:http://linkedlifedata.com/resource/pubmed/id/19853397

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-11-9
pubmed:abstractText
Recent progress in sensor technology has led to the development and application of electronic taste sensing systems. Especially taste prediction of pharmaceutical formulations is a matter of particular interest and is increasingly performed using electronic tongues. Several studies have dealt with electronic tongues before, but an analytical approach describing successfully conducted qualification has not been reported yet. Performance qualification of the taste sensing system SA402B (Insent Inc., Atsugi-chi, Japan) equipped with seven lipid membrane sensors was undertaken with special regard to bitter taste assessment. These sensors represent the gustatory stimuli bitterness, umami, saltiness, sourness, and the nociceptive sensation astringency. Specificity, linearity, range, accuracy, precision, detection and quantitation limit as well as robustness were established for each sensor type referring to ICH guideline Q2 (R1). Some items mentioned in the guideline were applicable whereas others had to be modified due to differences of the system to other commonly used analytical techniques. Quinine hydrochloride being one of the bitterest drugs served as model substance. A large range of linearity (0.01-100mM) with corresponding precision (RSD<4%) was found for most sensors. One sensor had a lower detection threshold (0.0025mM) for quinine hydrochloride than humans typically have. Different methods for determination of detection and quantitation limits were implemented and discussed with respect to rationality and feasibility. Therefore the approach based on visual evaluation was found as most adequate. An adapted guidance following ICH guideline Q2 was developed serving qualification of taste sensing systems in the future.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1873-264X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
5
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
497-506
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Performance qualification of an electronic tongue based on ICH guideline Q2.
pubmed:affiliation
Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University Duesseldorf, Universitaetsstr. 1, 40225 Duesseldorf, Germany. Katharina.Woertz@uni-duesseldorf.de
pubmed:publicationType
Journal Article, Comparative Study