Source:http://linkedlifedata.com/resource/pubmed/id/19851667
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2009-10-23
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pubmed:abstractText |
BACKGROUND - Multibacillary (MB) leprosy may be manifested with antiphospholipid antibodies (aPL), among which anti-beta2GP1 (beta2-glycoprotein 1). High titers of aPL are associated with APS (Antiphospholipid Syndrome), characterized by thrombosis. The mutation Val247Leu in the domain V of beta2GP1 exposes hidden epitopes with consequent development of anti-beta2GP1 antibodies.
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pubmed:language |
por
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1806-4841
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
355-9
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pubmed:meshHeading |
pubmed-meshheading:19851667-Antiphospholipid Syndrome,
pubmed-meshheading:19851667-Autoantibodies,
pubmed-meshheading:19851667-Female,
pubmed-meshheading:19851667-Humans,
pubmed-meshheading:19851667-Leprosy, Multibacillary,
pubmed-meshheading:19851667-Male,
pubmed-meshheading:19851667-Middle Aged,
pubmed-meshheading:19851667-Mutation,
pubmed-meshheading:19851667-Polymorphism, Genetic,
pubmed-meshheading:19851667-beta 2-Glycoprotein I
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pubmed:year |
2009
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pubmed:articleTitle |
[Val247Leu polymorphism of beta2 glycoprotein 1 gene may justify the genesis of anti beta2GP1 antibodies and antiphospholipid syndrome in multibacillary leprosy].
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pubmed:affiliation |
Faculdade de Medicina de Ribeirão Preto, USP, São Paulo, SP, Brasil.
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pubmed:publicationType |
Journal Article,
English Abstract,
Research Support, Non-U.S. Gov't
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