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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-2-1
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pubmed:abstractText |
Tolerance to alloantigen may be induced in rats by administration of blood followed by transplantation of a renal allograft. The mechanism of this tolerance was investigated by directly analyzing the functional activity of graft-infiltrating cells. We have previously shown cytotoxic T lymphocyte infiltration of, and major histocompatibility complex induction on, grafts of tolerant animals. We now report that cells isolated from the grafts of tolerant rats show a reduced expression of the p55 interleukin 2 receptor (IL-2R) chain on the cell surface compared with that seen on the cells of untreated animals. Scatchard analysis further reveals low expression of high affinity IL-2R. This is due to reduced transcription of both IL-2R alpha and beta chain mRNAs and results in a reduced ability of cells to proliferate in response to IL-2. Cells isolated from tolerant animals are unable to make biologically active IL-2 in culture, whereas cells from untreated animals make high levels. This is not reflected at the mRNA level as the IL-2 gene is induced in both tolerant and untreated animals to similar levels. The induction of tolerance is abrogated by administration of recombinant IL-2 to animals at the time of transplantation. Thus, we conclude that an altered regulation of the IL-2 pathway results in tolerance in these alloantigen-treated and transplanted animals.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-1971916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-2113314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-2137200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-2137201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-2308634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-2434833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-2457547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-2511629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-2526369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-2531194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-2540528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-2647894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-2650306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-2786608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-2788130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-2884454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-2955418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-2983318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-2999980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-3021852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-3260350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-3278440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-3282359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-3494522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-3546578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-3546583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-3881767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-3918306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-4563200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-6090574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-6240025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1985127-6324170
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
173
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79-87
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1985127-Animals,
pubmed-meshheading:1985127-Immune Tolerance,
pubmed-meshheading:1985127-Interleukin-2,
pubmed-meshheading:1985127-Isoantigens,
pubmed-meshheading:1985127-Male,
pubmed-meshheading:1985127-Polymerase Chain Reaction,
pubmed-meshheading:1985127-RNA, Messenger,
pubmed-meshheading:1985127-Rats,
pubmed-meshheading:1985127-Rats, Inbred Lew,
pubmed-meshheading:1985127-Receptors, Interleukin-2,
pubmed-meshheading:1985127-T-Lymphocytes,
pubmed-meshheading:1985127-Transplantation, Homologous,
pubmed-meshheading:1985127-Transplantation Immunology
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pubmed:year |
1991
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pubmed:articleTitle |
Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway.
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pubmed:affiliation |
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, England.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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