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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-11-20
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pubmed:abstractText |
The purpose of this work was to investigate for the first time the potential biomedical applications of novel polypyrrole (PPy) composites incorporating a large polyelectrolyte dopant, poly (2-methoxy-5 aniline sulfonic acid) (PMAS). The physical and electrochemical properties were characterized. The PPy/PMAS composites were found to be smooth and hydrophilic and have low electrical impedance. We demonstrate that PPy/PMAS supports nerve cell (PC12) differentiation, and that clinically relevant 250 Hz biphasic current pulses delivered via PPy/PMAS films significantly promote nerve cell differentiation in the presence of nerve growth factor (NGF). The capacity of PPy/PMAS composites to support and enhance nerve cell differentiation via electrical stimulation renders them valuable for medical implants for neurological applications.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1741-2552
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
065002
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19850977-Aniline Compounds,
pubmed-meshheading:19850977-Animals,
pubmed-meshheading:19850977-Biocompatible Materials,
pubmed-meshheading:19850977-Cell Culture Techniques,
pubmed-meshheading:19850977-Cells, Cultured,
pubmed-meshheading:19850977-Electric Impedance,
pubmed-meshheading:19850977-Electric Stimulation,
pubmed-meshheading:19850977-Hydrophobic and Hydrophilic Interactions,
pubmed-meshheading:19850977-Mice,
pubmed-meshheading:19850977-Nerve Growth Factor,
pubmed-meshheading:19850977-Neurites,
pubmed-meshheading:19850977-Neurogenesis,
pubmed-meshheading:19850977-Neurons,
pubmed-meshheading:19850977-PC12 Cells,
pubmed-meshheading:19850977-Polymers,
pubmed-meshheading:19850977-Pyrroles,
pubmed-meshheading:19850977-Rats,
pubmed-meshheading:19850977-Sulfonic Acids
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pubmed:year |
2009
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pubmed:articleTitle |
Electrical stimulation promotes nerve cell differentiation on polypyrrole/poly (2-methoxy-5 aniline sulfonic acid) composites.
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pubmed:affiliation |
ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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