Angiotensin (Ang) II-induced apoptosis was reported to be mediated by different signaling molecules. Whether these molecules are either interconnected in a single pathway or constitute different and alternative cascades by which Ang II exerts its apoptotic action, is not known.
Angiotensin II-induced oxidative stress resets the Ca2+ dependence of Ca2+-calmodulin protein kinase II and promotes a death pathway conserved across different species.
Centro de Investigaciones Cardiovasculares, Facultad de Medicina, Universidad Nacional de La Plata, Centro Científico Tecnológico CONICET, La Plata, Argentina.
