Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
44
pubmed:dateCreated
2009-11-5
pubmed:abstractText
Constitutive androstane receptor CAR (NR1I3) has been identified as a central mediator of coordinate responses to xenobiotic and endobiotic stress. Here we use leptin-deficient mice (ob/ob) and ob/ob, CAR(-/-) double mutant mice to identify a metabolic role of CAR in type 2 diabetes. Activation of CAR significantly reduces serum glucose levels and improves glucose tolerance and insulin sensitivity. Gene expression analyses and hyperinsulinemic euglycemic clamp results suggest that CAR activation ameliorates hyperglycemia by suppressing glucose production and stimulating glucose uptake and usage in the liver. In addition, CAR activation dramatically improves fatty liver by both inhibition of hepatic lipogenesis and induction of beta-oxidation. We conclude that CAR activation improves type 2 diabetes, and that these actions of CAR suggest therapeutic approaches to the disease.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-11756317, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-12376703, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-12756287, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-12920182, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-14075694, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-14742670, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-14755340, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-14770177, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-15096593, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-15107969, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-15220184, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-15266058, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-15340055, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-15466941, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-15671906, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-16101572, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-16460269, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-16485039, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-16492670, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-16492734, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-16557297, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-16740637, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-17189208, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-1764030, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-17948939, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-17965553, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-18177724, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-18187584, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-18369453, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-18598135, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-18941143, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-19617349, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-2446787, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-2501061, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-2833324, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-3896900, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-6851415, http://linkedlifedata.com/resource/pubmed/commentcorrection/19850873-9600904
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1091-6490
pubmed:author
pubmed:issnType
Electronic
pubmed:day
3
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
18831-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.
pubmed:affiliation
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
More...