Linked Life Data

19850756

Source:http://linkedlifedata.com/resource/pubmed/id/19850756

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-12-23
pubmed:abstractText
SUMMARY: The computational inference of ancestral genomes consists of five difficult steps: identifying syntenic regions, inferring ancestral arrangement of syntenic regions, aligning multiple sequences, reconstructing the insertion and deletion history and finally inferring substitutions. Each of these steps have received lot of attention in the past years. However, there currently exists no framework that integrates all of the different steps in an easy workflow. Here, we introduce Ancestors 1.0, a web server allowing one to easily and quickly perform the last three steps of the ancestral genome reconstruction procedure. It implements several alignment algorithms, an indel maximum likelihood solver and a context-dependent maximum likelihood substitution inference algorithm. The results presented by the server include the posterior probabilities for the last two steps of the ancestral genome reconstruction and the expected error rate of each ancestral base prediction. AVAILABILITY: The Ancestors 1.0 is available at http://ancestors.bioinfo.uqam.ca/ancestorWeb/.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1367-4811
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
130-1
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Ancestors 1.0: a web server for ancestral sequence reconstruction.
pubmed:affiliation
Department of Computer Science, Université du Québec à Montréal, PO. Box 8888 Downtown Station, Montreal, QC H3C3P8, Canada. diallo.abdoulaye@uqam.ca
pubmed:publicationType
Journal Article