Linked Life Data

19850476

Source:http://linkedlifedata.com/resource/pubmed/id/19850476

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
2009-11-5
pubmed:abstractText
A preliminary library of novel N(6),5'-bis-ureidoadenosine analogs and related derivatives was prepared and tested for activity against the NCI 60 panel of human cancers. A 2'-O-TBS group was found to be necessary, but not sufficient, for optimal antiproliferative activity. Neither the N(6)- nor 5'-ureido substituents were sufficient to achieve significant antiproliferative effects when present in the absence of the other. The 2'-O-TBS, and N(6),5'-bis-ureido substitution patterns were found to be necessary for optimal antiproliferative activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1464-3405
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6775-9
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Preliminary SAR analysis of novel antiproliferative N(6),5'-bis-ureidoadenosine derivatives.
pubmed:affiliation
Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, United States. matt_peterson@byu.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't